血小板疾病中原癌基因c-myc、c-myb的研究进展  

Progress of Research on Proto-oncogene c-myc,c-myb in Platelet Diseases——Review

作　　者：张莹[1] 陈蕊[1] 赵丽[1] 

机构地区：[1]兰州大学第一医院中心实验室,甘肃兰州730000

出　　处：《中国实验血液学杂志》2011年第1期274-278,共5页Journal of Experimental Hematology

摘　　要：原癌基因c-myc和c-myb对造血系统有重要的调节作用。c-myc基因表达的变化与细胞增殖、分化状态有关,其表达产物在调节细胞生长、分化或恶性转化中发挥作用。c-myb参与转录,影响细胞增殖、分化、凋亡。近年来,随着分子生物学、分子免疫学、细胞生物学等相关技术的日趋成熟,原癌基因c-myc、c-myb在造血调控中的研究逐渐增多。研究发现,巨核-红系祖细胞的定向分化及血小板的异常与其表达水平有关。常见的血小板疾病见于血小板减少症、血小板增多症等,此类疾病的病因和发病机制尚未明了。本文就c-myc和c-myb基因的结构、功能及其在血小板疾病中的表达水平与意义作一综述。The Proto-oncogene c-myc and c-myb has been shown to be crucial in the development of the hematopoietic system.The changes in the expression of c-myc are concerned the cell proliferation and differentiation,the expression products of which play an important regulatory role in cell growth,differentiation or malignant transformation.The c-myb involves in transcription and affects cell proliferation,differentiation,apoptosis.More recently,the researches on proto-oncogene c-myc,c-myb in hematopoietic regulation have gradually increased along with development of molecular biology,molecular immunology and cell biology.Scientists point out that the directive differentiation of erythroid and megakaryocytic progenitors,and platelet abnormalities all relate to the level of their expressions.The most common thrombocytopathy includes thrombocytopenia,thrombocytosis and so on.The etiology and the mechanism of these diseases are unknown.This article reviews the structure,function and the expression of c-myc and c-myb in platelet diseases and their significance.

关 键 词：原癌基因 C-MYB C-MYC 血小板疾病 

分 类 号：R558[医药卫生—血液循环系统疾病]