青牛胆化学成分的研究  

A Study on Chemical Constituents of Tinospora sagittata

作　　者：王世平[1] 吴艳俊[1] 李玲[1] 张金娟[1] 吴君[1] 

机构地区：[1]贵阳医学院机能学实验室,贵州贵阳550004

出　　处：《贵阳医学院学报》2011年第1期9-10,14,共3页Journal of Guiyang Medical College

基　　金：国家自然科学基金资助项目(No.30471592)

摘　　要：目的:对青牛胆的化学成分进行研究。方法:应用硅胶、Sephadex LH-20、RP-18柱色谱进行分离、纯化,根据理化常数和光谱分析鉴定结构。结果:从青牛胆中分离出5个化合物,经鉴定为:20β-羟基蜕皮素(Ⅰ)、金果榄苷(Ⅱ)、非洲防己碱(Ⅲ)、尖防己碱(Ⅳ)、药根碱(Ⅴ)。结论:化合物Ⅴ为首次从该植物中分离得到。Objective：To study the chemical constituents of Tinospora sagittata.Methods： Various chromatographic techniques including silica gel,Sephadex LH-20,and RP-18 trabeculum were used to isolate the constituents of T.sagittata,and their structures were identified by spectral and chemical methods.Result： Five compounds were isolated from T.sagittata,and their structures were identified as 20β-hydroxy-ecdysone（Ⅰ）,tinoside（Ⅱ）,columbamine（Ⅲ）,acutumine（Ⅳ）,and jatrorrhizine（Ⅴ）.Conclusion： This is the first report that compound Ⅴbeing isolated from T.sagittata.

关 键 词：色谱法 薄层 青牛胆 化学成分 

分 类 号：R284.1[医药卫生—中药学]