阿司匹林对衰老模型大鼠学习记忆能力的影响  

Effects of aspirin on spatial learning and memory in aging rat model

作　　者：巩睿智[1] 陈丽[2] 魏涛[1] 余玲[1] 杨璠[1] 李伟[1] 张仑[1] 宋燕州[1] 王兴会[3] 

机构地区：[1]西安交通大学医学院第一附属医院临床医学系,陕西西安710061 [2]西安交通大学医学院生理学与病理生理学系,陕西西安710061 [3]西安交通大学医学院机能教学实验中心,陕西西安710061

出　　处：《西安交通大学学报（医学版）》2011年第2期184-186,共3页Journal of Xi’an Jiaotong University（Medical Sciences）

基　　金：国家级大学生创新性实验计划项目(No.091069836)~~

摘　　要：目的观察阿司匹林对衰老模型大鼠学习记忆能力的影响。方法采用皮下注射D-半乳糖生理盐水溶液制备衰老大鼠模型。不同剂量阿司匹林以及阳性治疗药物处理后,采用Morris水迷宫行为检测方法观察大鼠学习记忆能力。结果与未治疗的衰老模型大鼠相比,小、中剂量阿司匹林应用后,大鼠平均逃避潜伏期明显缩短,穿越站台的次数显著增加;而大剂量阿司匹林处理大鼠的逃避潜伏期和穿越站台次数均无明显变化。结论适当剂量的阿司匹林能够改善衰老模型大鼠的学习记忆能力,而大剂量阿司匹林反而加剧衰老模型大鼠的精神症状。Objective To observe the effects of aspirin on spatial learning and memory in aging rat model.Methods D-galactose was injected subcutaneously once per day to prepare the aging rat models.After administration of aspirin or therapeutic drug,Morris water maze was used to examine the capability of learning and memory by detecting the mean latencies and the times to cross the target.Results Small and medium doses of aspirin decreased the mean latencies and increased the times to cross the target of aging rats.However,no significant difference was found in the mean latencies and the times to cross the target between large-dose aspirin group and aging model group without aspirin treatment.Conclusion A moderate dose of aspirin can improve the capability of learning and memory in aging rat model,but superabundant aspirin aggravates mental symptoms of aging rats.

关 键 词：阿司匹林 衰老模型 学习记忆 MORRIS水迷宫 

分 类 号：Q426[生物学—神经生物学] R338[生物学—生理学]