胼胝体与穹窿连合纤维的来源与发育  

Origins and development of corpus callosum and fornix commissures in mice

作　　者：吴萍[1] 邓同兴[1] 赵慧杰[1] 李明善[1] 邓锦波[1] 

机构地区：[1]河南大学神经生物学研究所,开封475004

出　　处：《解剖学杂志》2011年第1期81-84,共4页Chinese Journal of Anatomy

基　　金：国家自然科学基金面上项目（30771140,30670688,31070952）;河南省教育厅自然科学研究项目（2007180008）;河南大学自然科学基金项目（2008YBGG048,05YBZR031）

摘　　要：目的：研究小鼠胼胝体联合和穹窿连合的发生、发育以及细胞来源.方法： 利用快蓝活体示踪和DiI离体示踪技术对不同日龄的胚胎以及生后胼胝体联合和穹窿连合进行了顺行和逆行示踪.结果： 穹窿连合约在胚胎第16天左右形成,而胼胝体连合在胚胎18天左右形成.穹窿连合的纤维主要由海马CA3区锥体细胞、门细胞及内嗅皮质和下托锥体细胞所发出,而胼胝体联合可以由位于新皮质Ⅱ～Ⅵ层神经细胞所投射.结论： 胼胝体连合在细胞来源和分布上的广泛性是大脑半球两侧新皮质之间大量的信息交换的需要.Objective： To investigate the origin and development of corpus callosum and fornix commissures. Methods： The prenatal and postnatal corpus callosum and fornix commissures at various ages in mice were labeled anterogradely and retrogradely with fast blue tracing in vivo and DiI tracing in vitro. Results： Fornix commissure was formed at embryonic day 16, and corpus callosum commissure was formed at about embryonic day 18. The fibers of fornix rose from the pyramidal cells of CA3, hilus, subiculum and entorhinal cortex. However, fornix fibers were projected by the neurons from layers Ⅱ-Ⅵ of neocortex. Conclusion： The widely cellular distribution of corpus callosum is required of the numerous message communications between two neocortices.

关 键 词：胼胝体 发育 穹窿连合 示踪 

分 类 号：R322.81[医药卫生—人体解剖和组织胚胎学]