聚乳酸凝胶对兔术后腹腔粘连的疗效  

Experimental research on the prevention of abdominal cavity adhesion with the polylactic acid gel

作　　者：童晓春[1] 李幼林[1] 窦巩昊[1] 

机构地区：[1]温州市第三人民医院普外科,浙江温州325000

出　　处：《肝胆胰外科杂志》2011年第1期29-30,34,共3页Journal of Hepatopancreatobiliary Surgery

摘　　要：目的探讨聚乳酸凝胶预防腹腔粘连的疗效。方法将大白兔随机分为实验组和对照组,在全麻下于兔回盲部结肠人工形成创面并切除对应的壁层腹膜建立肠粘连动物模型。实验组创面均匀涂布聚乳酸凝胶,对照组创面不予处理,分别于术后2周和12个月行大体、光镜和电镜观察。结果术后2周实验组粘连分级比对照组低(P<0.05);术后12个月实验组粘连分级比对照组明显低(P<0.01)。结论聚乳酸凝胶可有效减少大白兔术后腹腔粘连的发生。Objective To investigate the prevention of abdominal cavity adhesion with polylactic acid gel.Methods Thirty white rabbits were divided into the experiment group and control group.A manual wound was formed on the the ascending colon of every rabbit under general anesthesia and the corresponding parieral peritoneum was removed,meanwhile,the polylactic acid gel was covered on the wounds of rabbits in the experiment group and nothing was covered on the wounds of rabbits in the control group.The rabbits were sacrificed after 2 weeks/12 months respectively.The tissues of wounds were observed by naked eye/microscope/electron microscope.Results The grade of abdominal cavity adhesion in the experiment group was lower than in the control group 2 weeks later（P0.05）,and the grade of abdominal cavity adhesion in the experiment group was apparently lower than in thecontrol group 12 months later（P0.01）.Conclusion The polylactic acid gel can prevent of abdominal cavity adhesion efficiently.

关 键 词：聚乳酸凝胶 腹腔粘连 疗效 

分 类 号：R656[医药卫生—外科学]