皮肌炎伴泛发性钙沉着症一例  

Dermatomyositis coupled with extensive calcinosis： a case report

作　　者：程芳[1] 陈浩[1] 张磊[1] 李小静[1] 刘毅[1] 孙建方[1] 

机构地区：[1]中国医学科学院北京协和医学院皮肤病研究所,南京210042

出　　处：《国际皮肤性病学杂志》2011年第2期64-65,共2页International Journal of Dermatology and Venereology

摘　　要：患者男,25岁,皮肌炎病史10年,2年前开始于腰部出现皮下钙沉着,并迅速发展为躯干四肢广泛的钙沉着,伴活动受限.患者入院时肌无力症状显著,全身大片紫红色水肿性斑片,指关节活动受限,呈屈曲位,躯干四肢可触及大片不规则质硬肿块,肌酶升高显著.给予泼尼松、甲氨蝶呤、羟氯喹治疗4周后,患者皮损、肌酶及肌无力症状明显改善.采用地尔硫（艹卓）进行试验性治疗,仍在随访中.A case of dermatomyositis coupled with extensive calcinosis is reported. A 25-year-old male presented with a 10-year history of dermatomyositis. Two years prior to the presentation, subcutaneous calcinosis emerged on the waist, and rapidly involved the trunk and limbs with limited mobility. On admission,the symptom of amyasthenia was remarkable with extensive prunosus and edematous macules all over the body surface, many large firm irregularly-sized subcutaneous masses on the trunk and limbs, limited mobility of knuckles in the flexed posture. There was also a marked increase of serum creatase. After treatment with prednisone, methotrexate, hydroxychloroquine for 4 weeks, an evident improvement was observed in the lesions and amyasthenia along with a reduction in serum creatase level. The use of diltiazem was attempted to manage calcinosis in this patient, who was still under follow up till the time of this writing.

关 键 词：皮肌炎 钙质沉着症 地尔硫(艹卓) 

分 类 号：R593.26[医药卫生—内科学]