新生隐球菌荚膜毒力作用的研究进展  

Advances in Cryptococcus neoformans capsule as a virulence factor

作　　者：胡婵[1] 朱红梅[1] 温海[1] 

机构地区：[1]第二军医大学长征医院皮肤科,上海200003

出　　处：《国际皮肤性病学杂志》2011年第2期118-120,共3页International Journal of Dermatology and Venereology

基　　金：基金项目：国家自然科学基金（30500441）

摘　　要：新生隐球菌是重要的机会致病真菌,其胞外包裹的荚膜被公认为隐球菌关键的毒力因子.近年来,研究初步证明荚膜有抗吞噬细胞吞噬作用.另外,荚膜在新生隐球菌感染扩散过程中以及诱导宿主细胞凋亡中均发挥了关键的作用.概述荚膜的抗吞噬作用及荚膜在感染扩散中的作用等,对这些机制的探讨将有助于理解新生隐球菌的致病机制,同时为治疗新生隐球菌病提供新的靶位点.Cryptococcus neoformans is an important conditional pathogenic fungus and capsule is widely acknowledged to be a key virulence factor of it. It has been proved that capsule posseses antiphagocytosis acitivity, and plays an essential role in the dissemination of C. neoformans infection and induction of apoptosis in host cells. The review describes the roles of capsule in antiphagocytic process and dissemination of C. neoformans infection, which will help to better understand the pathogenic mechanism of cryptococcosis and to provide new therapeutic targets for cryptococcosis.

关 键 词：隐球菌 新型 荚膜 毒力 

分 类 号：R379[医药卫生—病原生物学]