血脂及载脂蛋白水平对冠心病的诊断价值  

The value of serum lipid profiles in evaluation of coronary heart disease

作　　者：王治[1] 黄进[1] 戴剑[1] 曹恒献[1] 汤涌[1] 陆治平[1] 吴晓馗[1] 丁畅[1] 王林林[1] 王倩[1] 

机构地区：[1]南京市胸科医院心血管病科,210029

出　　处：《江苏医药》2011年第4期445-447,共3页Jiangsu Medical Journal

摘　　要：目的探讨冠心病患者血脂及载脂蛋白水平对冠心病的诊断价值。方法冠状动脉造影阳性的患者为冠心病组(A组,80例);其中,单支病变亚组36例(A1组),多支病变亚组44例(A2组)。冠状动脉造影阴性的患者为对照组(C组,75例)。测定各组血清总胆固醇(TC)、低密度脂蛋白-胆固醇(LDL-C)、高密度脂蛋白-胆固醇(HDL-C)、甘油三酯(TG)、脂蛋白a(Lpa)、载脂蛋白AI(ApoAI)、载脂蛋白B(ApoB),计算ApoB与ApoAI的比值(ApoB/ApoAI)。结果 A组ApoB水平和ApoB/ApoAI比值均高于C组[(0.74±0.18)g/L vs.(0.66±0.16)g/L和(0.67±0.19)vs.(0.60±0.19)](P<0.05)。A2组LDL-C水平高于A1组[(3.05±0.84)mmol/L vs.(2.55±0.75)mmol/L](P<0.05)。结论 ApoB水平及ApoB/ApoAI比值对于冠心病的诊断具有一定的临床意义;LDL-C水平对于判断冠脉病变的范围则有一定的价值。Objective To investigate the value of serum lipid profiles in evaluation of coronary heart disease（CHD）.Methods Reported by coronary angiography,115 patients were divided into without CHD（group C,75 cases） and with CHD（group A,80 cases）,of whom 36 cases with single-vessel disease（group A1） and 44 cases with multiple-vessel disease（group A2）.Serum total cholesterol（TC）,low-density lipoproteins（LDL-C）,high-density lipoproteins（HDL-C）,triglycerides（TG）,lipoprotein a（Lpa）,apolipoprotein AI（ApoAI） and apolipoprotein B（ApoB） were measured.The ratio of ApoB to ApoAI was calculated.Results Serum level of ApoB and the ratio of ApoB to ApoAI were significantly higher in group A than that in group C [（0.74±0.18）g/L vs.（0.66±0.16）g/L and（0.67±0.19） vs.（0.60±0.19）]（P0.05）.Serum concentration of LDL-C in group A2 was higher than that in group A1 [（3.05±0.84）mmol/L vs.（2.55±0.75）mmol/L]（P0.05）.Conclusion Both serum ApoB level and ApoB/ApoAI ratio has a certain value in predicting CHD.Examination of LDL-C is useful to evaluate the extent of coronary artery lesions.

关 键 词：冠心病 载脂蛋白 

分 类 号：R541[医药卫生—心血管疾病]