姜黄消痤凝胶对兔耳粉刺模型的抗角化作用  

Experimental Study on Anticomedone Effect of Anti-acne Gel of Curcuma in Rabbit Ear Acne Model

作　　者：鲁瑾[1,2] 曹煜[1] 

机构地区：[1]贵阳医学院皮肤科,贵州贵阳550001 [2]贵州省人民医院皮肤科,贵州贵阳550002

出　　处：《中国皮肤性病学杂志》2011年第3期192-195,共4页The Chinese Journal of Dermatovenereology

摘　　要：目的采用煤焦油制造实验兔耳粉刺模型,观察姜黄消痤凝胶(AGC)对动物粉刺模型的抗角化作用。方法将30只雄性大耳白兔随机分为模型组、基质组、AGC低剂量组、AGC高剂量组和阳性对照组。造模成功后,模型组兔右外耳道不外搽任何药物作为模型对照,后四组分别在右外耳道每日外用空白凝胶基质1g,AGC1g,AGC2g和维A酸乳膏1g,连用3周后,肉眼和组织学观察AGC抗粉刺作用。结果外涂煤焦油2周后,兔耳表面粗糙、增厚,可见粉刺,组织学改变与人类粉刺相似;给药2周后AGC组和阳性组肉眼可见兔耳变薄、变软,粉刺减少或消退,组织学亦有相应变化。结论 AGC对实验性粉刺有缩小毛囊面积、皮脂腺直径、减轻表皮增厚和减轻真皮炎症细胞浸润等作用。Objective To establish an experimental acne model of rabbit ear by coal tar to observe the effect of anti-acne gel of cureuma （ACC） on the aene animal model. Methods Thirty male rabbits were randomly divided into model group, base group, AGC low dosage, AGC high dosage and positive control group. After successful modeling, the model rabbits which right auricular tube were not administered with any drugs were in the model group, the other four groups were treated respective}y with base gel （1g） .AGC （1g） ,AGC （2g）, Tretinoin Cream （1 g） for external use everyday. After 3 weeks, observing the AGC anti-ache effects by naked eye observation as well as histology observation. Results After using the coal tar for 2 weeks, the surface of ears became rougber and thicker, and the comedo could be seen, and the histology change was similar to that of human eomedo. Two weeks after giving AGC and Tretinoin Cream, the ears became thinner and softer, and the eomedo was decrease and extincted, and the change could be seen in histology. Conclusion AGC can reduce the area of hair follicle, the diameter of sebaceous gland, the thickness of epidermis, and inflammatory cell infiltration in dermis.

关 键 词：姜黄 凝胶 痤疮 粉刺动物模型 

分 类 号：R758.733[医药卫生—皮肤病学与性病学]