低水平锰接触对焊工血清神经内分泌激素水平的影响  

Effects of low level manganese exposure on the serum neuroendocrine hormones in the welders

作　　者：王禅[1] 陆继培[1] 姜岳明[1] 马南花[2] 覃卫平 罗海兰[1] 黄艳妮[1] 陈海滨[4] 

机构地区：[1]广西医科大学公共卫生学院,南宁530021 [2]广西南宁市第二人民医院 [3]广西职业病防治研究院 [4]广西南宁市疾病预防控制中心

出　　处：《中华劳动卫生职业病杂志》2011年第2期94-97,共4页Chinese Journal of Industrial Hygiene and Occupational Diseases

基　　金：国家“十一五”科技支撑重点项目（2006BA106802）;广西自然科学基金（0991129）

摘　　要：目的探讨低水平锰接触对焊工血清神经内分泌激素水平的影响。方法选择广西某厂41名男性焊工为接触组，某单位不接触锰烟尘及其他有害物质的40名男性工人为对照组，采用化学发光免疫法测定血清中催乳素（PRL）、促黄体生成素（LH）、尿促卵泡素（FSH）、睾酮（TST）、促甲状腺激素（TSH）含量。结果焊工作业环境空气MnO2几何平均浓度为0．03mg／m^2（0．003～0．519mg／m^2），接触组红细胞锰和尿锰明显高于对照组，差异均有统计学意义（P〈0．01）。接触组血清LH、TSH水平[（2．89±0．69）mlU／ml、（1．45±0．56）μIu／m1]明显低于对照组[（3．82±1．61）mIU／ml、（2．19±1．28）μIU／ml]，差异均有统计学意义（P〈0．01）。接锰工龄〈5年组血清LH、FSH、TSH水平明显低于对照组，TST水平明显高于对照组和5～年组，FSH明显低于≥10年组，差异均有统计学意义（P〈0．05，P〈0．01）。接锰工龄5～年组血清LH、TSH水平明显低于对照组，差异均有统计学意义（P〈0．05或P〈0．01）；接锰工龄≥10年组血清PRL、LH、TSH水平明显低于对照组，差异均有统计学意义（P〈0．05）。红细胞锰与尿锰呈负相关（r=-0．310，P〈0．05），血清PRL与TST呈负相关（r=-0．409，P〈0．01），LH与FSH正相关（r=0．361，P〈0．05）。结论长期低水平锰接触可能会致工人血清PRL、LH和TSH水平下降，对神经内分泌激素代谢产生一定的影响。Objective To study the effects of low level manganese （Mn）exposure on the serum neuroendocrine hormones levels of the welders. Methods The exposure group consisted of 41 male welders, 40 male workers without exposing to harmful agents served as controls. The serum contents of prolaetin （PRL）, luteinizing hormone （LH）, follicle stimulating hormone （FSH）, testosterone （TST） and thyroid stimulating hormone （TSH） of 81 subjects were detected by chemiluminescence immunoassay. Results The geometric mean value of airborne Mn concentrations was 0.03 mg/m3 （0.003-0.519 mg/m3） in the welding circumstances. The levels of Mn in red blood cells（ RBCs ） and urinary Mn of the exposure group were significantly higher than those of control group （P〈0.01）. The contents of serum LH and TSH of the exposure group were 2.89±0.69 mlU/ml and 1.45±0.56 μIU/ml, which were significantly lower than those （3.82±1.6） μIU/ml and 2.19±1.28 μIU/ml ） of control group （P〈0.01 ）. The serum contents of LH, FSH and TSH of the group exposed to Mn for 〈5 years were significantly lower than those of the control group, The serum TST level of the group exposed to Mn for 〈5 years was significantly higher than those of the control group and group exposed to Mn for 5-years, the serum FSH level of the group exposed to Mn for 〈 5 years was significantly lower than that of the group exposed to Mn for 10 years （P〈0.05 or P〈0.01 ）. The serum contents of LH and TSH of the group exposed to Mn for 5-years were significantly lower than those of the control group （P〈0.05 or P〈0.01 ）. The serum contents of PRL, LH and TSH of the group exposed to Mn for 10 years were significantly lower than those of the control group（P〈0.05 ）. There was negative correlation between blood（ RBC ） Mn and urinary Mn（r=-0.310, P〈0.05 ）, also there was negative correlation between serum PRL and serum TST （r=-0.409, P〈0.01 ）, the positive correlation between serum LH and serum FSH was observed

关 键 词：锰 锰中毒 焊接 神经内分泌系统 激素类 

分 类 号：R1[医药卫生—公共卫生与预防医学]