布-加综合征地理分布与饮用水碘含量的关系  

Study of correlation between the geographical distribution of Budd-Chiari syndrome with iodine content in drinking water

作　　者：肖培瑞[1] 蔺新英[1] 郭成浩[2] 边建朝[3] 杨晓霞[4] 王金彪[5] 

机构地区：[1]山东大学营养与食品卫生学研究所,济南250012 [2]山东大学医学院病理学与病理生理学研究所,济南250012 [3]山东省地方病防治研究所研究所,济南250014 [4]山东省地方病防治研究所特检科,济南250014 [5]山东省地方病防治研究所碘病科,济南250014

出　　处：《临床肝胆病杂志》2011年第2期130-133,共4页Journal of Clinical Hepatology

基　　金：国家自然科学基金资助项目(30772134);山东省科技厅资助项目(2006BS03029)

摘　　要：目的探讨外周环境饮用水中碘含量与布-加综合征发病的关系。方法选择1995～2004年菏泽市立医院等5家医院收治的居住地为山东菏泽且可以查到地址的342例布-加综合征患者为研究对象,对其性别、年龄、饮用水中碘含量进行描述性分析;以2003年山东省菏泽地区各乡镇的水碘中位数为依据,建立菏泽地区布-加综合征患者空间分布图,并对水碘与布-加综合征关系进行空间统计分析。以2000年第5次人口普查数据为依据,计算菏泽各县布-加综合征发病率,并对各县布-加综合征发病率与水碘值中位数进行线性相关分析。结果男女性别比为1.71:1。患者年龄为(40.30±12.97)岁,300例患者分布于25～64岁年龄段。菏泽地区布-加综合征患者所在乡镇的水碘含量范围为12.62～681.21μg/L,中位数为262.05μg/L。89.18%患者所在乡镇的水碘值>150μg/L,水碘浓度与布-加综合征发病率呈正相关(r=0.846,P=0.008)。结论布-加综合征的发生可能与饮用水中碘含量过高有关,高碘在布-加综合征发病过程中的作用还有待进一步的研究。Objective To discover the relationship between iodine content of drinking water and morbidity of Budd-Chiari syndrome.Methods 342 cases of BCS,whose addresses were found to be from Heze area of Shandong province in China,were randomly selected from five hospitals including Heze Municipal Hospital during the year 1995 to 2004.Considering the gender and age and iodine content of drinking water,we established a map of spatial distribution of patients in Heze area and studied the relationship between iodine content of potable water and BCS using the spatial statistical analysis,based on the median iodine of various townships of Heze in Shandong province in 2003.Then the morbidity of BCS in heze area was counted and linear correlation analysis of the median of the morbidity and iodine content of drinking water was performed,.which was based on the population data from 2000 Population Census in China.Results The ratio of male to female was 1.71：1,and the average age of patients was 40.30±12.97,age distribution of the 300 cases was in between 25-64.years In Heze area where BCS cases exist,iodine content of drinking water was 12.62-681.21 μg/L and the median was 262.05 μg/L.Furthermore,iodine concentration was in positive correlation with the incidence of BCS（r=0.846,P=0.008）.Conclusion We speculated that the high iodine content of drinking water was one of the causes of BCS.and further study should be perform to determine the correlation.

关 键 词：BUDD-CHIARI综合征 碘 给水 

分 类 号：R657.34[医药卫生—外科学]