冠心病病人白细胞流变特性和细胞黏附分子及补体活化状态的变化  

THE CHANGES OF LEUKOCYTE RHEOLOGIC CHARACTERISTICS, CELL ADHESION MOLECULE AND COMPLEMENT ACTIVATION IN PATIENTS WITH CORONARY HEART DISEASE

作　　者：孙桂芝 张银亭[1,2] 纪新强 刘成玉[1,2] 

机构地区：[1]青岛市骨伤医院检验科 [2]青岛医学院

出　　处：《齐鲁医学杂志》1999年第2期82-82,共1页Medical Journal of Qilu

摘　　要：目的探讨冠心病病人白细胞流变特性、细胞黏附分子和补体激活状态的变化。②方法采用ＤＸＣ－３００Ａ型红细胞变形能力测定仪、体外血栓血小板黏附两用仪和酶联免疫吸附法，检测了７２例冠心病病人和６３例健康人白细胞变形能力（ＬＤ）、白细胞黏附率（ＬＡＲ）、血清可溶性细胞间黏附分子－１（ｓＩＣＡＭ－１）和血浆可溶性补体活化片段（ｓＣ５ｂ－９）浓度的变化。③结果冠心病病人红细胞滤过指数（ＬＦＩ）、ＬＡＲ，ｓＩＣＡＭ－１和ｓＣ５ｂ－９浓度均明显增高，与对照组比较差异有显著性（ｔ＝９．６４０～１４．５２５，Ｐ＜０．００１）。不稳定心绞痛（ＵＡ）、急性心肌梗死（ＡＭＩ）和陈旧性心肌梗死（ＯＭＩ）病人各指标比较差异亦具有极显著性（Ｆ＝１８．４７５～２１．４６０，ｑ＝８．７７６～１５．０８２，Ｐ＜０．００１），且以ＡＭＩ病人各指标增高最明显。冠心病病人ｓＣ５ｂ－９与ＬＦＩ，ＬＡＲ，ｓＩＣＡＭ－１呈正相关（ｒ＝０．７１９～０．７６８，Ｐ＜０．００１），ＬＦＩ和ＬＡＲ与ｓＩＣＡＭ－１呈正相关（ｒ＝０．６７９，０．７１２，Ｐ＜０．００１），ＬＦＩ与ＬＡＲ呈正相关（ｒ＝０．６７２，Ｐ＜０．００１）。④结论白细胞流变特性异常、ｓＩＣＡＭ－１和?Objective\ To explore the changes of leukocyte rheologic characteristics, cell adhesion molecule and complement activation in coronary heart disease( CHD) patients.\ Methods\ The leukocyte deformability (LD), leukocyte adhesion function (LAF), serum soluble intercellular adhesion molecule 1 (sICAM 1) and plasma soluble terminal complement components (sC 5b 9) concentration were measured in 72 CHD patients and 63 healthy subjects, by using erythrocyte deformability apparatus, thrombus and platelet adhesion dual purpose apparatus and enzyme linked immunosorbent assay (ELISA) methods. Results\ The leukocyte filtration index (LFI), leukocyte adhesion rate (LAR), sICAM 1 and sC 5b 9 concentration were significantly higher in CHD patients than those in control ( t=9.640-14.525, P <0.001). All indicators were significantly different among unstable angina (UA) , acute myocardial infarction (AMI) and old myocardial infarction (OMI) patients( F=18.475- 21.460 , q= 8.776 -15.082, P <0.001), and the increase of all indicators were more obvious in AMI patients. In CHD patients, sC 5b 9 was positively correlated with LFI, LAR and sICAM 1 concentration ( r=0.719-0.768, P <0.001), LFI and LAR were positively correlated with sICAM 1 ( r=0.679, 0.712, P <0.001). \ Conclusion\ The abnormalities of leukocyte rheologic characteristics, increase of sICAM 1 and sC 5b 9 concentration might participate in the occurance and development of CHD, and related to the degree of pathologic changes.

关 键 词：白细胞变形能力 细胞黏着分子 补体 冠心病 

分 类 号：R541.403[医药卫生—心血管疾病]