糖尿病肾病病人尿液特定蛋白检测及其意义  

THE DETECTION AND CLINICAL SIGNIFICANCE OF URINARY SPECIAL PROTEIN IN PATIENTS WITH DIABETIC NEPHROPATHY

作　　者：牟晓峰[1,2,3] 陈文[1,2,3] 刘泽刚 刘成玉[1,2,3] 刘淑云[1,2,3] 

机构地区：[1]青岛医学院第二附属医院检验科 [2]青岛医学院第二附属医院外科 [3]青岛医学院诊断学教研室

出　　处：《齐鲁医学杂志》1999年第2期85-87,共3页Medical Journal of Qilu

摘　　要：目的探讨糖尿病肾病（ＤＮ）病人２４ｈ尿液特定蛋白变化的意义。②方法采用免疫速率散射比浊法，检测了１２６例２型糖尿病（ＤＭ）病人和１１８例正常人的２４ｈ尿液清蛋白排泄率（ＵＡＥ），α１－微球蛋白（α１－Ｍ），β２－微球蛋白（β２－Ｍ），转铁蛋白（ＴＲＦ），免疫球蛋白Ｇ（ＩｇＧ）的变化。③结果ＤＭ病人、无ＤＮ病人、早期ＤＮ病人、临床ＤＮ病人的ＵＡＥ，α１－Ｍ，ＴＲＦ和ＩｇＧ明显高于对照组，差异有显著性（ｔ＝３．０３～８９．８５，Ｐ＜０．０１），而无ＤＮ和早期ＤＮ病人的β２－Ｍ与对照组比较差异无显著性（ｔ＝１．１６，１．５１，Ｐ＞０．０５）。ＤＮ病人较无ＤＮ组上述指标明显升高（ｔ＝１１．０２～５２．４８，Ｐ＜０．０１），临床ＤＮ组较早期ＤＮ组上述指标明显升高（ｔ＝５．８７～１９．４５，Ｐ＜０．０１）。ＤＮ病人的α１－Ｍ，ＴＲＦ，ＩｇＧ与ＵＡＥ呈正相关（ｒ＝０．５４７～０，９６４，Ｐ＜０．０１），而β２－Ｍ与ＵＡＥ无相关性（ｒ＝０．０３６，Ｐ＞０．０５）。④结论ＵＡＥ，α１－Ｍ，ＴＲＦ，ＩｇＧ对ＤＮ的早期诊断有重要意义，而β２－Ｍ对早期ＤＮ诊断无价值。Objective\ To explore the significance of changes of urinary special protein in patients with diabetic nephropathy (DN). \ Methods\ The changes of urinary special protein of 24 hours: urinary album excretion rate (UAE),α 1 microg lobulin(α 1 M),β 2 microglobulin(β 2 M),immunoglobulin G(IgG) and transferrin(TRF) were determined in 118 normal controls and 126 type 2 diabetes mellitus patients by immune rate nephelometry method. \ Results\ The UAE,the level of α 1 M,IgG and TRF in diabetes mellitus(DM) group, no DN group, early DN group and clinical DN group were significantly higher than those in control group( t=3.03-89.85,P <0.01), while urinary β 2 M in no DN group and early DN group was no significantly different than that in control group( t=1.16,1.51,P >0.05).The above indexes in DN group were significantly higher than those in no DN group( t=11.02-52.48,P <0.01),and the above indexes in clinical DN group were significantly higher than those in early DN group( t= 5.87 -19.45,P <0.01). Urinary α 1 M,TRF and IgG had significantly positive correlation with UAE ( r=0.547- 0.964 ,P < 0.01 ),while β 2 M had no correlation with UAE( r=0.036,P > 0.05 ).\ Conclusion\ The UAE,α 1 M,TRF and IgG had important value for the early diagnosis of DN,while β 2 M had no value.

关 键 词：糖尿病肾病 尿分析 蛋白质类 诊断 

分 类 号：R587.2[医药卫生—内分泌] R692.04[医药卫生—内科学]