急性心肌梗塞肌钙蛋白T检测的临床意义  

CLINICAL VALUE OF TROPONIN T MEASUREMENT IN ACUTE MYOCARDIAL INFARCTION

作　　者：牛虹[1] 李芝[1] 

机构地区：[1]南京医科大学第二附属医院心内科

出　　处：《河北医学》1999年第9期4-6,共3页Hebei Medicine

摘　　要：目的：为观察急性心肌梗塞（ａｃｕｔｅｍｙｏｃａｒｄｉａｌｉｎｆａｒｃｔｉｏｎＡＭＩ）心肌肌钙蛋白Ｔ（ｔｒｏｐｏｎｉｎＴＴｎＩ）的临床意义。方法：应用电化学发光免疫测定法检测３２例ＡＭＩ患者、３８例不稳定心绞痛（ｕｎｓｔａｂｌｅａｎｇｉｎａＵＡ）患者和３５例对照组患者血清ＴｎＴ、肌酸磷酸激酶同功酶（ｃｒｅａｔｉｎｅｋｉｎａｓｅｉｓｏｅｎｚｙｍｅＭＢＣＫ—ＭＢ），并进行比较分析。结果：ＡＭＩ组３１例（９６．８７％）ＴｎＴ阳性，３．６８ｎｇ／ｍｌ±５．１９ｎｇ／ｍｌ，仅１例（３．１３％）ＴｎＴ阴性；２７例（８４．３８％）ＣＫ—ＭＢ阳性，７．８４ｎｇ／ｍｌ±２．２６ｎｇ／ｍｌ，仅５例（１５．６２％）ＣＫ—ＭＢ阴性。ＵＡ组１１例（２８．９５％）ＴｎＴ阳性，０．８７ｎｇ／ｍｌ±０．６４ｎｇ／ｍｌ，其中２例住院期间发生心梗，２７例（７１．０５％）ＴｎＴ阴性；３７例（９７．３７％）ＣＫ—ＭＢ阴性，仅１例（２．６３％）ＣＫ－ＭＢ阳性。对照组血清ＴｎＴ、ＣＫ—ＭＢ均未超过正常上限（正常上限分别为＜０．１ｎｇ／ｍｌ、＜５ｎｇ／ｍｌ）。结论：ＴｎＴ比ＣＫ－ＭＢ反映心肌损伤更敏感、更具特异性。ABSTRACT Objective:To observe the clinical value of troponin T(TnT)in acute myocardial infarction(AMI).Methods:Serum cardiac TnT and creatine kinase isoenzyme MB(CK-MB)were detected by electro-chemiluminescent immunoassay in 32 patients with AMI;38patients with unstable angina (UA)and35 peoples with controls,and compared with analysis.Results:In AMI group,31 cases(96.87%) were positive for TnT,3.68 ng/ml±5.19ng/ml,1 case (3.13%)was negative for TnT,27 cases(84.38%)were positive for CK-MB,7.84ng/ml±2.26ng/ml,5 case (15.62%)were negative for CK-MB;In UA group,11 cases(28.95%)were positive for TnT,0.87ng/ml± 0.64ng/ml,2 cases of them had AMI in hospitalization period,27 cases(71.05%)was negative for TnT,37 cases(97.37%)were negative for CK-MB,1 cases(2.63%)was positive for CK-MB; In control group,TnT and CK-MB were not increased. (normal limits:TnT<0.1ng/ml,CK-MB<5ng/ml). Conclusion:The authors conclude that TnT than CK- MB in serum is a more sensitive and specific indication of myocardial injury,TnT have clinical value for diagnosis and progrosis of AMI KEY WORDS Myocardial infarction;TroponinT;Creatine kinase is oenzyme MB;Electrochemiluminescent immunoassay

关 键 词：心肌梗塞 肌钙蛋白T 肌酸磷酸激酶 同功酶 

分 类 号：R542.22[医药卫生—心血管疾病]