社区老年高血压人群的血浆NT-proBNP水平与心室舒张功能的关系  

Relationship between serum NT-proBNP level and diastolic function in eldly patients with systemic aterial hypertension

作　　者：史力斌[1] 杨颖[1] 张宝娓[1] 齐丽彤[1] 霍勇[1] 丁文惠[1] 

机构地区：[1]北京大学第一医院心内科,北京100034

出　　处：《中国临床药理学杂志》2011年第3期163-166,176,共5页The Chinese Journal of Clinical Pharmacology

摘　　要：目的评价老年高血压患者的血浆NT-proBNP水平与心室舒张功能的关系。方法 254例无明显靶器官损害的60岁以上高血压患者,分析其血浆NT-proBNP水平与临床因素、超声心动图指标的相关性。结果 NT-proBNP水平的增高,与年龄、诊断高血压年限呈正相关(分别P<0.01,P<0.05);而与应用钙拮抗剂负相关(P<0.05);与反映心脏舒张功能的指标(E/A,E/E′)即左心房容积及IVRT呈正相关(分别P<0.05,P<0.01,P<0.05及P<0.01)。向心性肥厚患者的lgNT-proBNP水平较离心性肥厚患者增高(1.89±0.31 vs1.87±0.37,P<0.05)。结论无靶器官损害的老年高血压人群血浆NT-proBNP水平升高可能与心室舒张功能减退相关。Objective To evaluate the relationship between serum N-terminal-pro-brain natriuretic peptide（NT-proBNP） levels and ventricular diastolic function in eldly patients with systemic aterial hypertension.Methods We enrolled 254 patients with systemic aterial hypertension.All patients were older than 60 years old,without diagnosed heart disease,cerebral artery disease or renal insufficiency.Serum NT-proBNP level were measured in every patient.Ventricular function was evaluated by echocardiography and tissue doppler image（TDI）.Results The increase of NT-proBNP levels has a positive correlation with age and history of hypertension（P0.01,P0.05）,and has a negative correlation with usage of calcium antagonist（P0.05）.Also the increase has a positive correlation with E/A ratio,E/Ea ratio,left atrium volume and IVRT（P0.05,P0.01,P0.05 and P0.01,respectively）.Serum NT-proBNP level was higher in concentric hypertrophy group than in eccentric hypertrophy group.（Log transformation：1.89±0.31 vs 1.87±0.37,P0.05）.Conclusion Increasement of serum NT-proBNP in eldly patients was correlated with left ventricular diastolic dysfunction.

关 键 词：氨基末端脑钠肽前体 老年高血压 舒张功能减退 心室重构 

分 类 号：R544.1[医药卫生—心血管疾病] R972.4[医药卫生—内科学]