米非司酮配伍米索前列醇终止10～16周妊娠256例临床观察  

A CLINICAL OBSERVATION BETWEEN JOINTADMINISTRATION OF MIFEPRISTON ANDMISOPROSTEL FOR TERMINATING 10-16 WEEK256 CASES OF PREGNANCY

作　　者：熊小娟[1] 李承华[1] 王春梅[1] 方园[1] 丁兴琳 

机构地区：[1]九江市妇幼保健院

出　　处：《九江医学》1999年第2期81-83,共3页Jiujiang Medical Journal

摘　　要：目的：观察米非司酮配伍米索前列醇终止孕１０～１６周妊娠的临床效果。方法：对２５６例孕１０～１６周妇女，随机分为两组，一组（１４４例）给予米非司酮口服（为米索组），另一组（１１２例）给予利凡诺羊膜腔注射（为利凡诺组），观察两组的有效流产率、钳刮率及平均出血量。结果：两组有效流产率分别为９３７５％和７６７９％；钳刮率为０和１７５８％（Ｐ＜０００１）。平均出血量分别为７１１８±５５７５ｍＬ和１０１３４±７３９２ｍｌ（Ｐ＜００１）。结论：米非司酮配伍米索前列醇终止孕１０～１６周妊娠优于传统的利凡诺，可明显减少钳刮和流产出血量，作为一种非侵入性方法，简便、安全、有效，值得推广。OBJECTIVE: To determine the therapeutic effect of joint administration of mifepriston and misoprostel for terminating 10-16 week 256 cases of pregnancy. METHOD: 256 cases of pregnant women were divided into two groups at random.One group was given mifepriston by oral administration and another group was given rivanol by intra-amniotic injection.The abortion rate and uterine curettage rate were compared in the two groups.RESULTS: 9375% women in mifepriston group and 7679% in rivanol group were successfully induced abortion.No women in mifepriston group and 1758% women in rivanol group need curettage (P<0001).The average bleeding was 711855 mL and 101347392 mL in the two group (P<001). CONCLUSION: Mifepriston joint with misoprostel is obviously better than rivanol in terminating 1016 week pregnancy and reducing uterine curettage rate as well as bleeding.It can be widely use clinically for its non-invasion,safety and convenience.

关 键 词：药物流产 米非司酮 米索前列醇 

分 类 号：R169.42[医药卫生—公共卫生与预防医学]