粉防己碱抗肿瘤的作用及机制研究进展  

Progress of Research on Anti-tumor Effect and Mechanisms of Tetrandrine

作　　者：刘锦裕[1] 李永生[2] 黄玉清[1] 

机构地区：[1]福建医科大学协和临床医学院,福州350001 [2]福建医科大学附属协和医院,福州350001

出　　处：《中国现代应用药学》2011年第3期205-208,共4页Chinese Journal of Modern Applied Pharmacy

基　　金：福建省科技计划项目(2007F3036)

摘　　要：目的探讨粉防己碱在抗肿瘤方面的作用及其机制的研究进展。方法检索、整理、归纳粉防己碱抗肿瘤方面作用的文献。结果粉防己碱能抑制肿瘤的生长;并可通过抗氧化作用来降低肿瘤的发生率;还可通过去除放射引起的G2/M期阻滞从而产生放射增敏作用;此外还有减轻放、化疗不良反应的作用。结论粉防己碱可通过多种机制来实现抗肿瘤作用。OBJECTIVE To investigate the progress in effects on anti-tumor and its mechanisms of tetrandrine. METHODS Literatures about the effects of tetrandrine on anti-tumor and its mechanisms have been reviewed and analyzed. RESULTS Tetrandrine can inhibit the growth of tumor cells. It also can reduce the incidence of tumor by antioxidation. Moreover, it can enhance the sensitivity to radiation by abrogating the G2/M arrest induced by X-ray. Finally, it can reduce the toxic reaction caused by radiotherapy and chemotherapy. CONCLUSION Tetrandrine plays a great important role in anti-tumor though several different kinds of mechanism.

关 键 词：粉防己碱 抗肿瘤 逆转多药耐药 凋亡 

分 类 号：R285.6[医药卫生—中药学] R979.19[医药卫生—中医学]