青蒿素脂质体的制备及质量评价  

Preparation and Quality Evaluation of Artemisinin Liposomes

作　　者：瞿建江[1] 冯淑华[2] 李可意[2] 

机构地区：[1]扬州大学医学院,江苏扬州225001 [2]北京联合大学生物化学工程学院,北京100023

出　　处：《中国现代应用药学》2011年第3期251-256,共6页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的通过对青蒿素脂质体的处方和制备工艺研究,研制高包封率和稳定的脂质体。方法采用乙醇注入法制备脂质体,以正交实验优化处方。测定了脂质体中药物的包封率;并初步考察了脂质体的稳定性。结果优化处方与工艺所得脂质体形态均匀,包封率>85%,载药量达27.22%,粒径约为90 nm,Zeta电位约为-68.4 mV,具有良好的稳定性。结论乙醇注入法制备脂质体工艺简便,包封率高,制备的脂质体稳定性好。OBJECTIVE To get a stable artemisinin liposome with high trapping efficiency by selecting formulation and preparation of artemisinin liposome. METHODS The artemisinin liposomes were prepared by film-ultrasound method. The formulation was optimized by orthogonal design. The trapping efficiency and the stability were determined. RESULTS The trapping efficiency of the artemisinin liposome reached 85%, the drug amounted to 27,22%, the particle size of the liposome was 90 nm and the Zeta potential was -68.4 mV. The liposome had good stability. CONCLUSION The method can be used to prepare a stable artemisinin liposome with high trapping efficiency.

关 键 词：青蒿素 脂质体 包封率 质量评价 

分 类 号：R283.5[医药卫生—中药学] R943.3[医药卫生—中医学]