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机构地区:[1]湖南中医药大学第一附属医院,长沙410208 [2]湖南中医药大学,长沙410208
出 处:《中药新药与临床药理》2011年第2期141-144,共4页Traditional Chinese Drug Research and Clinical Pharmacology
基 金:湖南省自然科学基金资助项目(08JJ4008).湖南省自然科学基金重点资助课题(09JJ3073);湖南省教育厅科研基金重点项目(07A050);教育部博士点基金资助课题(2009432311002)
摘 要:目的探讨脑泰方提取物对缺血脑组织CD34表达的影响。方法 30只SD大鼠随机分为假手术组、模型组、脑复康组、脑泰方低、中、高剂量组。通过月桂酸钠损伤血管内皮细胞来复制局灶性脑缺血模型,采用免疫组化方法检测各组大鼠缺血脑组织CD34的表达。结果脑缺血后,CD34微血管呈阳性表达,脑泰方提取物中、高剂量组表达高于模型组(P<0.05)。结论脑泰方提取物能够增强缺血脑组织CD34的表达,促进局部血管新生和微血管的建立。Objective To investigate the effects of Naotai Recipe extracts on the cerebral CD34 expression in rats with focal cerebral ischemia.Methods Thirty Sprague-Dawley(SD) rats were randomly divided into 6 groups: sham-operation group,model group,Naofukang group,and low-,middle-,and high-dosage Naotai Recipe extracts group.Focal cerebral ischemia model was established through sodium-laurate-induced injury of vascular endothelial cells,and CD34 expression was detected by the immunohistochemical method.Results After cerebral ischemia,CD34 expression was found to be positive in some capillary vessels.Moreover,CD34 expression levels in middle-and high-dosage Naotai Recipe extracts group was higher than that in the model group(P 0.05).Conclusion Naotai Recipe extracts are helpful for enhancing cerebral CD34 expression of focal cerebral ischemia and promote the local angiogenesis and the growth of capillary vessels.
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