荷叶降脂汤对代谢综合征伴高尿酸血症患者尿酸及胰岛素抵抗的影响  

Effect of Folium nelumbinis reducing blood fat decoction （荷叶降脂汤） on uric acid and insulin resistance in patients with metabolic syndrome disease with hyperuricemia

作　　者：金涛[1] 王挺挺[2] 于伟[1] 乔樵[1] 汪国荣[1] 

机构地区：[1]浙江省中医院,浙江杭州310006 [2]浙江中医药大学,浙江杭州310053

出　　处：《中国中西医结合急救杂志》2011年第2期89-91,共3页Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care

基　　金：浙江省中医药科技计划项目（2002C028）

摘　　要：目的观察荷叶降脂汤治疗代谢综合征（MS）伴高尿酸血症（HuA）患者的临床疗效及其对胰岛素抵抗（IR）的影响。方法采用区组随机对照试验，将91例MS伴HuA患者分为两组。治疗组56例，服用自拟荷叶降脂汤（荷叶30g，水蛭6g，制黄精30g，制首乌30g，地肤子30g，蒲黄9g，泽泻12g），每日1剂；对照组35例，口服别瞟呤醇0．1g，每日3次；两组均以2个月为1个疗程。观察两组治疗后体质指数（BMI）、空腹血糖（FPG）、血尿酸（uA）、血脂、空腹胰岛素（FINS）、胰岛素抵抗指数（HOMA—IR）的变化及临床疗效，并记录不良反应发生情况。结果两组治疗后BMI、FPG、UA、总胆固醇（TC）、三酰甘油（TG）、FINS、HOMA—IR均较治疗前明显改善；且治疗组UA、TC、TG、FINS、HOMAIR改善程度明显优于对照组[UA（μmol／L）：385．03±32．18比390．36±43．15，TC（mmol／L）：5．8±1．2比6．0±1．5，TG（mmol／L）：1．4±0．5比1．8±0．8，FINS（mU／L）：19．5±4．2比25．8±6．7，HOMA—IR：2．3±o．8比4．5±1．1，均P〈O．051。治疗组UA、FPG的愈显率（89．280A、71．43％）和复发率（5．36％、28．57％）均明显低于对照组（愈显率：97．14％、94．28％，复发率：85．71％、88．57％，P〈0．05或P〈0．01）。治疗组除2例有胃肠道不适外，无其他不良反应。结论荷叶降脂汤治疗MS伴HUA患者有较好的临床疗效，并能改善IR。Objective To observe the clinical therapeutic effect of Folium nelumbinis reducing blood fat decoction （荷叶降脂汤） on blood uric acid （UA） and insulin resistance （IR） in patients with metabolic syndrome （MS） disease accompanied by hyperuricemia （HUA）. Methods Ninety-one patients with MS and HUA were randomly divided into two groups. Fifty-six patients in treatment group were treated by Folium nelumbinis reducing blood fat decoction 1 dose everyday [Folium nelumbinis （荷叶） 30 g, Hirudo （水蛭） 6 g, Rhizoma polygonati （制黄精） 30 g, Caulis polygoni multiflori （制首乌） 30 g, Fructus kochiae （地肤子） 30 g, Pollen typhae （蒲黄） 9 g, Rhizoma alismatis （泽泻） 12 g] orally; 35 patients in control group were treated by allopurinol 0.1 g, orally 3 times per day. Both groups were treated for 2 months. The changes of body mass index （BMI）, fasting blood-glucose （FPG）, UA, blood lipid, fasting insulin （FINS）, insulin resistance index （HOMA-IR） were observed, and therapeutic effects and the adverse reactions were recorded in both groups. Results After treatment, the levels of BMI, FPG, UA, total cholesterol （TC）, triglyceride （TG）, FINS, HOMA-IR were all improved in the two groups, and the levels of UA, TC, TG, FINS, HOMA-IR were improved more significantly in the treatment group than those in the control group [UA （μmol/L） ： 385.03± 32.18 vs. 390.36±43.15, TC （mmol/L）： 5.84±1.2 vs. 6.0±1.5, TG （mmol/L）： 1.4±0.5vs. 1.8＋0.8, FINS （mU/L）：. 19.5±4.2 vs. 25.8±6.7, HOMA-IR： 2.3±0.8 vs. 4.5±1.1, all P〈0. 053. The obvious effective rates （89.28%, 71.43%） and recurrent rates （5. 36%, 28.57%） of UA and FPG in treatment group were all better than those in control group （obvious effective rate.. 97. 14%, 94. 28%; recurrent rate： 85.71%, 88.57%, P〈0.05 or P〈0.01）. Except 2 cases had gastrointestinal discomfort, there was no other adverse reactions in the treatment group. Conclusion Folium

关 键 词：荷叶降脂汤 高尿酸血症 代谢综合征 胰岛素抵抗 

分 类 号：R285.6[医药卫生—中药学] R587[医药卫生—中医学]