大剂量血塞通注射液对不稳定型心绞痛患者血小板聚集率的影响  

Effect of Xuesaitong （血塞通） on platelet aggregation rate in unstable angina patients

作　　者：孙东升[1] 黄惠玲[1] 黄慧芳[1] 

机构地区：[1]浙江省人民医院干部科,浙江杭州310014

出　　处：《中国中西医结合急救杂志》2011年第2期92-93,共2页Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care

摘　　要：目的观察血塞通对不稳定型心绞痛（UA）患者的疗效及可能机制。方法将86例入本院治疗的UA患者按随机原则以入院顺序分为常规治疗组和血塞通组，每组43例。常规治疗组给予常规抗心绞痛治疗；血塞通组在常规治疗基础上加用血塞通400mg静脉滴注，每日1次，共10d。治疗后观察两组疗效及治疗前后血小板聚集率的变化。结果血塞通组显效率和总有效率均明显高于常规治疗组（显效率：65．12％比39．53％，总有效率：88．37％比74．42％，均P〈0．05）。两组治疗前血小板聚集率无明显差异；治疗后两组血小板聚集率均较治疗前明显下降[常规治疗组（60．58±18．17）％比（69．84±16．05）％，血塞通组（47．34±14．15）％比（69．80±13．47）％，P〈0．05和P〈0．01]，且血塞通组较常规治疗组下降更明显（P〈0．01）。结论血塞通可有效缓解心绞痛症状，其作用机制可能与血塞通的抗血小板聚集作用有关。Objective To investigate the effect of Xuesaitong （血塞通） on platelet aggregation rate in unstable angina （UA） patients and its possible mechanism. Methods Eighty-six UA patients were randomly divided into Xuesaitong group and control group, with 43 cases in each group, and both of them received conventional anti-angina therapy. On the basis of conventional therapy, patients in Xuesaitong group additionally were given Xuesaitong injection 400 mg once a day for 10 days. The therapeutic effect and changes of platelet aggregation rates before and after treatment of both groups were recorded. Results The patients in Xuesaitong group had obviously higher significant effective rate and total efficiency than those of the control patients （significant effective rate： 65.12% vs. 39.53% total efficiency： 88. 37% vs. 74.42%, both P〈 0.05）. There was no significant difference in platelet aggregation rates between two groups before the treatment. The platelet aggregation rates after treatment were markedly lowered in the two groups compared with those before the treatment [control group： （60.58±18.17）% vs. （69.84± 16.05）%, Xuesaitong group： （47.34±14.15）% vs. （69.80±13.47）%, P〈0.05 and P〈0.01[. The decrease in platelet aggregation rate in patients of Xuesaitong group was more remarkable than that in the control group （P〈0.01）. Conclusion Xuesaitong combined with conventional anti-angina therapy is much more effective for UA patients, and the effect is possibly associated with the reduction of platelet aggregation rate.

关 键 词：血塞通 心绞痛 血小板聚集 

分 类 号：R285.6[医药卫生—中药学] R256.2[医药卫生—中医学]