游离脂肪酸导致内质网应激的机制及其治疗  

The mechanism of endoplasmic reticulum stress caused by free fatty acids and its treatment

作　　者：金晶[1] 胡耀敏[1] 刘伟[1] 

机构地区：[1]上海交通大学医学院附属仁济医院内分泌科,200127

出　　处：《国际内分泌代谢杂志》2011年第2期125-127,共3页International Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金资助项目（30670988）;浦东新区社会发展局卫生科技项目（PW2008D-1）

摘　　要：内质网是参与细胞蛋白质、脂质合成的重要细胞器，并且参与钙离子的储存及其信号转导。游离脂肪酸通过破坏内质网结构及钙离子稳态、导致蛋白从内质网到高尔基体的转运障碍，引起未折叠或错误折叠蛋白质在内质网中蓄积，激活内质网应激。内质网应激是多种疾病的病理生理基础，研究游离脂肪酸与内质网应激的关系，对了解疾病的发病机制及指导治疗有重要意义。Endoplasmic reticulum（ER） is an important organelle with a central role in lipid and protein biosynthesis ,Ca^2＋ storage and signal transduetion. Free fatty acids（FFAs） lead to the accumulation of unfolded or misfolded proteins in ER by disrupting ER structure and homeostasis of Ca2＋ , blocking ER-to- Golgi proteins trafficking and so on. Ultimately,ER stress is induced. Moreover, ER stress is the pathophysiological basis of many diseases. Therefore, investigating the relationship between FFA and ER stress can help to understand the pathogenesis of the diseases and guide to treatment.

关 键 词：游离脂肪酸 内质网应激 未折叠蛋白反应 治疗 

分 类 号：R589[医药卫生—内分泌]