复方苦参注射液联合化疗对大肠癌术后化疗患者免疫功能的影响  

Effects of matrine injection on immune functions in patients with colorectal carcinoma undergoing chemotherapy after surgery

作　　者：黄琳[1] 李彬[1] 胡作为[1] 郭培中[1] 

机构地区：[1]武汉市第一医院肿瘤科三病区,武汉430000

出　　处：《中国新药杂志》2011年第6期526-528,共3页Chinese Journal of New Drugs

摘　　要：目的:探讨复方苦参注射液对大肠癌术后化疗患者细胞免疫功能的影响。方法:60例大肠癌术后化疗患者随机分为复方苦参注射液观察组和对照组;两组在进行术后化疗的同时,复方苦参注射液观察组静脉点滴复方苦参注射液,对照组不加用本药;两组术后1个月内进行FOLFOX方案化疗,每21 d为1个周期,共化疗6个周期,化疗前1 d及化疗1周后测定血液分析及淋巴细胞亚群。结果:化疗后:对照组中,患者的外周血白细胞计数为(3.2±1.7)×109·L-1,而复方苦参注射液观察组中外周血白细胞计数为(4.9±2.5)×109·L-1。在复方苦参注射液观察组中,CD 4+及CD 8+阳性细胞的百分率分别为(37.8±2.4)%和(41.6±1.7)%,对照组分别为(30.4±1.5)%和(25.4±1.5)%,高于对照组(P<0.01)。结论:复方苦参注射液具有降低化疗药物的毒性、减轻化疗后骨髓抑制、增强患者免疫功能的作用。Objective：To evaluate the effects of compound matrine injection on immune functions in patients with colorectal carcinoma undergoing chemotherapy after surgery.Methods：Sixty patients with colorectal carcinoma undergoing chemotherapy after surgery were randomly divided into 2 groups（n=30 in each group）.Half of them were treated with compound matrine injection.FOLFOX chemotherapy was used in both groups for 6 cycles（21 days for a cycle） after one month of surgery.The blood routine and immunoglobulin of the patients were examined 1 day before and 1 week after chemotherapy.Results：Number of white blood cells was（3.2±1.7）×10^9·L-1 in control group and（4.9±2.5）×10^9·L-1 in compound matrine injection group.The percentages of CD＋8 and CD＋4 T lymphocytes were significantly higher in compond matrine injection group[（41.6±1.7）% and（37.8±2.4）%] than in control group[（25.4±1.5）% and（30.4±1.5）%]（P〈0.01）.Conclusion：Compound matrine injection attenuates toxicity of chemical drugs,reduces the myelosuppression,and strengthens the immunity in patients with colorectal carcinoma undergoing chemotherapy after surgery.

关 键 词：复方苦参注射液 大肠癌 全身化疗 免疫功能 

分 类 号：R979.1[医药卫生—药品]