宫腔灌注顺铂治疗功能失调性子宫出血10例  

Uterine infusion of cisplatin in treating 10 patients with dysfunctional uterine bleeding

作　　者：赵巧 邱学华[1] 

机构地区：[1]第四军医大学唐都医院妇产科,陕西西安710038

出　　处：《第四军医大学学报》1999年第10期895-896,共2页Journal of the Fourth Military Medical University

摘　　要：目的： 探索宫腔灌注顺铂治疗功能失调性子宫出血（功血）的疗效． 方法： 选１０例无生育要求的功血患者，将１０ｍ ｇ 顺铂稀释至１０ ｍ Ｌ，每次注入宫腔６ ｍ Ｌ～８ ｍ Ｌ， ４次为一疗程． 结果： １０例患者中６例既往月经过多者治疗后月经量明显减少；４例经期延长者治疗后经期变为正常． ６例复查宫内膜病理变化，其中４例子宫内膜单纯增生过长，１例囊腺样增生及１例腺瘤样增生者，治疗一个疗程后均转变为分泌期内膜．结论： 宫腔灌注顺铂可逆转宫内膜病理变化，减少子宫出血量及缩短出血时间．AIM: To explore the uterine infusion of cisplatin in treating dysfunctional uterine bleeding. METHODS: Ten cases with dysfunctional uterine bleeding and no further desire for pregnancy were selected. 10 mg cisplatin was diluted to 10 mL and 6 to 8 mL was infused into the uterine of every case once a week. Four times made up one course of treatment. RESULTS: After treatment, 6 from the 10 cases with menorrhagia displayed significantly diminished menstrual flow. Menstruation of the other 4 cases with previous lengthened menstrual bleeding became normal. Endometrium of 6 cases with endometrial hyperplasia ( n =4), cystic glandular hyperplasia ( n =1) and adenomatous hyperplasia ( n =1) was transformed as secretive phase of endometrium after one course of treatment. CONCLUSION: Uterine infusion of cisplatin can transform inversely histological change of endometrium, decrease menstrual flow as well as shorten the bleeding duration, which can be applied in the treatment of dysfunctional uterine bleeding.

关 键 词：子宫出血 治疗 顺铂灌注 功能性 

分 类 号：R711.520.5[医药卫生—妇产科学]