盐酸曲马多缓释胶囊的制备及药动学研究  

Studies on the Sustained-Release Microtablet Capsule of Tramadol and Its Human Pharmacokinetics

作　　者：朱颖[1] 平其能[1] 

机构地区：[1]中国药科大学药剂学教研室,南京210009

出　　处：《中国药科大学学报》1999年第5期340-342,共3页Journal of China Pharmaceutical University

摘　　要：研制了盐酸曲马多缓释微片胶囊,研究了其人体内药物动力学。其体外释放行为符合一级动力学过程,体内配置状态以一室模型描述较为适宜。药动学参数为Ka=0.4864h-1,K=0.0898h-1,Cmax=234.3ng／ml,Tmax＝5.7h,AUC0→∞（ng／ml·h）＝4244.Sustained-release microtablet capsules of Tramadol (SRMT) were studied. The drug release pattern in vutro was best described by first-order kinetics and tn vico profile was demonstrated to fit one compartment model.The pharmacokinetic parameters are Ka =0. 4 864 h-1, K=0.0898 h-1, Cmax=23 4. 3 ng/ml, Tmax=5.7 h, AUC0→∞ (ng/ml·h)=424 4. 38 respectively.

关 键 词：盐酸曲马多 缓释胶囊 药物动力学 镇痛药 

分 类 号：R971.2[医药卫生—药品]