HPLC法测定复方美沙芬缓释片的释放度和含量  

Determination of in Vitro Release and Content of Dextrome thorphan Hydrobromide and Pseudoephedrine Hydrochloride Sustained-Release Tablets by HPLC

作　　者：张建军[1] 蒋曙光[1] 屠锡德[1] 

机构地区：[1]中国药科大学药剂学教研室,南京210009

出　　处：《中国药科大学学报》1999年第5期364-366,共3页Journal of China Pharmaceutical University

摘　　要：采用HPLC法测定复方美沙芬缓释片释放度和含量。该法采用YWG-C18色谱柱,以乙腈-醋酸钠溶液-高氨酸-三乙胺（40：60：0.5：0.1）为流动相,能同时测定制剂中伪麻黄碱和氢溴酸右美沙芬,精密度好,峰面积与浓度呈良好线性关系,回收率约100％,RSD＜1.5％。Determination of release and content of compound dextromethorphan sustuined release tablets by HPLC was established. This stationary phase was YWG-C18, the mobile phase was composed of the mixture of acetonitrile and CH3COONa buffer. This condition for analysis can meet the requirements to determinate simultaneously the release and contents of pseudoephedrine and dextromethorphan hydrobromide in preparation. It was a precise method and the mean recovery was nearly 100%, RSD<1. 5%. The peak area was in good corre1ation with concentration for both drugs.

关 键 词：复方美沙芬 HPLC 释放度 含量测定 缓释片 

分 类 号：R971.1[医药卫生—药品] R927.2[医药卫生—药学]