氟比洛芬酯复合曲马多用于骨科下肢手术后静脉镇痛效果观察  

Application of intravenous flurbiprofen axeyil injection combined with tramadol hydrochloride for postoperative analgesia in patients underwent orthopedic surgery of lower limb

作　　者：李勇[1] 代春英[1] 陆松虹[1] 

机构地区：[1]安徽省蚌埠市第三人民医院麻醉科,233000

出　　处：《蚌埠医学院学报》2011年第3期263-265,共3页Journal of Bengbu Medical College

摘　　要：目的:探讨氟比洛芬酯复合曲马多术后静脉镇痛的临床效果和不良反应。方法:选择择期骨科下肢手术40例,随机分为氟比洛芬酯复合曲马多组(A组)(氟比洛芬酯100 mg+曲马多1 000 mg+昂丹司琼8 mg)和曲马多组(B组)(曲马多1 200mg+昂丹司琼8 mg);每组总量均为100 ml。镇痛模式为背景流量2 ml/h,自控剂量每次0.5 ml,锁定时间15 min。观察24 h内视觉模拟评分(VAS)、患者自控镇痛按压次数及术后镇痛的不良反应发生情况。结果:术后8 h时B组的VAS高于A组(P<0.05),而24、和24 h的VAS 2组差异均无统计学意义(P>0.05)2,组恶心、呕吐的发生率差异均无统计学意义(P>0.05),不良反应总发生率A组低于B组(P<0.05)。镇痛期间均无嗜睡、呼吸抑制及异常出血等并发症发生。结论:氟比洛芬酯复合曲马多用于骨科下肢手术后静脉镇痛效果良好,是一种安全、有效的镇痛方法。Objective：To explore the analgesic effects and side effect of intravenous postoperative anlgesia with flurbiprofen axeyil injection combined with tramadol hydrochloride. Methods：Forty cases undergoing orthopedic surgery of lower limb were randomly divided into two groups with twenty cases each：flurbiprofen axeyil injection 100 mg＋tramadol hydrochloride 1 000 mg＋ondansetron hydrochloride 8 mg（A group）,tramadol hydrochloride 1 200 mg＋ ondansetron hydrochloride 8 mg（B group）.The drugs in each group were diluted to 100ml.Analgesic pattern was background flow rate 2 ml/h with 0.5 ml self-controlled dose every time.Locking time was 15 min.The VAS score,pressing times and incidence of side effects were recorded during the period of postoperative 24 hours. Results：The VAS of group B at 8 h after operation was higher than that of group A（P〈0.05）,while the VAS of group B at 2,4,24 h were similar as group A（P〉0.05）.The accidence rate of nausea,vomiting in two groups were similar（P〉0.05）.The total accidence rate of group A was lower than that of group B（P〈0.05）.No respiratory depression or abnormal bleeding occurred in two groups. Conclusions：Intravenous postoperative analgesia with flurbiprofen axeyil injection combined with tramadol hydrochloride has a better analgesic effect than tramadol hydrochloride alone and was a safe and effective therapy.

关 键 词：镇痛药 氟比洛芬酯 曲马多 骨科手术 

分 类 号：R971.1[医药卫生—药品]