维生素B_1、B_2、C及烟酸对热暴露果蝇保护作用的研究  

STUDIES ON THE PROTECTION OF VB_1,VB_2,VC AND NICOTINIC ACID ON THE HEAT-EXPOSED DROSOPHILA

作　　者：邱璐[1] 郭俊生[1] 赵法[1] 沈志雷[1] 杨林[1] 

机构地区：[1]第二军医大学军队卫生学教研室,上海200433

出　　处：《解放军预防医学杂志》1999年第5期324-328,共5页Journal of Preventive Medicine of Chinese People's Liberation Army

基　　金：全军医药卫生科研基金

摘　　要：目的：探讨维生素Ｂ１ 、Ｂ２ 、Ｃ 及烟酸对机体的热保护作用及其可能的机理。方法：以果蝇为热暴露动物模型，以３６ ．５ ℃为热暴露温度，观察上述四种维生素的不同剂量干预下的果蝇的平均生存时间及热应激蛋白含量的变化。结果：除烟酸外，其余维生素均有一种或几种干预的剂量能显著增加果蝇的热生存时间及ＨＳＰ７０ 含量。结论：维生素Ｂ１ 、Ｂ２ 、Ｃ能显著增加果蝇生存时间，在有效剂量干预下果蝇的ＨＳＰ７０ 含量也增加，提示它们对果蝇具有热保护作用。Objective: It is to search the effects of heat protection of VB 1,VB 2,VC and NA(nicotinic acid), and their mechanisms. Methods: Drosophila melanogaster was regarded as heat-exposure model. Different levels of VB 1,VB 2,VC and NA were supplied to the diet of Drosophila. After three days, the survival time and the content of heat shock protein(HSP70) were studied on Drosophila at 36.5 ℃.Results:It was found that VB 1,VB 2 and VC significantly increased the survival time of heat-exposed Drosophila, and the content of HSP increased too. The effect of NA was not significant. Conclusion: The effective levels of VB 1,VB 2 and VC had protection on heat-exposed Drosophila and its mechanism could be related to the production of HSP70.

关 键 词：VB_1 VB_2 VC 烟酸 热暴露 生存时间 热应激蛋白 

分 类 号：R594.1[医药卫生—内科学] R135.3[医药卫生—临床医学]