大豆异黄酮对大鼠离体心肌缺血/再灌注损伤的保护作用  

Protective Effect of Soy Isoflavones on Myocardial Ischemia-Reperfusion Injury in Isolated Rat Hearts

作　　者：贾强[1] 杨锐[1] 刘小粉[1] 马善峰[1] 

机构地区：[1]安徽省蚌埠医学院生理学教研室,233030

出　　处：《中华全科医学》2011年第4期508-509,共2页Chinese Journal of General Practice

基　　金：安徽省高校省级自然科学研究计划项目(KJ2007B111)

摘　　要：目的观察大豆异黄酮对离体大鼠心脏缺血-再灌注(I/R)损伤的保护效应。方法本文采用Langendorff离体心脏灌流方法,通过心脏动力学实验对大豆异黄酮抗I/R效应进行研究。结果通过离体大鼠心脏动力学实验显示,缺血前药物各组心功能参数与对照组相比较,差异没有统计学意义(P>0.05);缺血后药物各组与对照组相比较,dp/dtmax与-dp/dtmax差异有统计学意义(P<0.01);再灌注后药物各组与对照组相比较,心率有改善,低剂量组差异有统计学意义(P<0.05)。低剂量、高剂量组与对照组相比较dp/dtmax与-dp/dtmax有显著改善(P<0.01)。结论心肌缺血再灌注可抑制心脏的舒缩功能,大豆异黄酮不影响离体心脏的正常功能,但能改善缺血后再灌注引起的心律失常的离体心脏功能,可促进I/R后心功能的恢复。Objective To study the effect of soy isoflavones（SI） against myocardium iscahemia-reperfusion injury in isolated rat hearts. Methods The isolated Langendorff heart peifusion method was used. The effect of soy isoflavones （SI） against myocardium iscahemia-reperfusion was studied by hemodynamics experiment. Results Hemodynamic experiment in vitro showed that cardiac dysfunction was induced by isehemia-reperfusion, the changes of left ventricular pressure, dp/dt and CF in groups of ischemia-reperfusion containing soy isoflavones（SI） was smaller than those groups of ischemia-reperfusion without soy isoflavones（SI）. It suggested that soy isoflavones（SI） could protect myoeardium against ischemia-reperfusion lesion. Condusion It was shown that soy isoflavones（SI） played an important role on protection ischemia-reperfusion induced cardiac dysfunction.

关 键 词：大豆异黄酮 缺血-再灌注(I/R) 心脏动力学 

分 类 号：R542.22[医药卫生—心血管疾病] R331.31[医药卫生—内科学]