急性冠脉综合症患者测定hsCRP、Nt-proBNP的临床意义  

Clinical Significance of High Sensitivity C-Reactive Protein and NT-ProBNP in Acute Coronary Syndrome

作　　者：韩霞[1] 亓维东[1] 朱宝华[1] 张增堂[1] 亓西霖[1] 

机构地区：[1]山东省莱芜市人民医院心内科,271100

出　　处：《中华全科医学》2011年第4期523-524,共2页Chinese Journal of General Practice

摘　　要：目的探讨联合检测氨基末端脑钠肽前体和高敏C反应蛋白(hsCRP)在急性冠状动脉综合征中的临床价值。方法将急性冠状动脉综合征(ACS)患者106例,分为不稳定型心绞痛组(UAP组)36例,急性非ST段抬高性心肌梗死组(NSTEMI组)37例与急性ST段抬高性心肌梗死组(STEMI组)33例;同期正常体检者30例作为对照组,分别检测血清氨基末端脑钠肽前体和高敏C反应蛋白水平,并进行比较。结果 ACS组血清氨基末端脑钠肽前体与高敏C反应蛋白水平显著高于对照组(P<0.05);NSTEMI组氨基末端脑钠肽前体水平高于UAP组(P<0.05);STEMI组氨基末端脑钠肽前体、高敏C反应蛋白水平高于NSTEMI组和UAP组(P<0.05);NSTEMI组与UAP组高敏C反应蛋白水平比较差异有统计学意义(P>0.05)。结论联合检测氨基末端脑钠肽前体和高敏C反应蛋白水平可判断急性冠状动脉综合征的严重程度,对其诊治及预后评价均有重要参考价值。Objective To study the significance of NT-proBNP and hsCRP in patients with acute coronary syndromes （ACS）. Methods The study comprised 106 patients with ACS. Group Ⅰ consisted of 36 patients with unstable angina peetoris（UAP）. Group Ⅱ consisted of 37 patients with myocardial infarction without ST segment elevation （NSTEMI）. Group Ⅲ consisted of 33 patients with myocardial infarction with ST segment elevation（STEMI）. In all patients, NT-proBNP and hsCRP were determined, the data were compared with those of 30 healthy controls. Results In ACS, the levels of NT-proBNP and hsCRP were higher those of healthy controls. The level of NT-proBNP in NSTEMI group was higher than that in UAP group;the levels of NT-proBNP and hsCRP in STEMI group were higher than those in NSTEMI group and UAP group;the difference of level of hsCRP between NSTEMI group and UAP group was statistically significant （ P 〈 0.05 ）. Conclusion The severity of ACS can be evaluated the combination determination of NT-proBNP and hsCRP, which was important to the diagnosis, treatment and prognosis of the dis- ease.

关 键 词：高敏C反应蛋白 NT—proBNP 急性冠脉综合症 

分 类 号：R541.41[医药卫生—心血管疾病]