硫酸腺嘌呤预处理对大鼠缺血心脏的保护机制  

Protective Mechanism of Adenine Sulphate Preconditioning on Ischemia Heart in Rats

作　　者：董传仁[1] 张友云[1] 卢彦珍 郑汉巧 马春艳[1] 刘永明 涂淑珍 

机构地区：[1]湖北医科大学基础医学院,武汉430071

出　　处：《基础医学与临床》1999年第5期70-72,共3页Basic and Clinical Medicine

基　　金：湖北省自然科学基金!95J31

摘　　要：本研究应用注入腺苷前质——硫酸腺嘌呤复制大鼠心脏预处理模型，通过与经典的预处理对比观察，探讨其机制，结果表明，两种方式的预处理是通过心肌CAT，5'－NT活性、血清NO含量的提高、降低心肌MDA含量与促进HSP70mRNA表达增强而显示预处理效应。A rat heart preconditioning model was established through the injection of adenine sulphate, theprecursor of adenosine. It was found to invoIve similar underlying mechanisms as the classical pre-conditioning model using adenosine - They involved elevation of myocardial CAT and 5-NT activities,increased serum NO, decrease of MDA content in the myocardium and speeding-up of HSP70 mRNAexpression, that brought preconditioning into effect.

关 键 词：心肌缺血 预处理 硫酸腺嘌呤 

分 类 号：R654.1[医药卫生—外科学]