IL-17、hs-CRP联合检测在急性冠脉综合征中的意义  

Significance of IL-17 and hs-CRP detected in patients with acute aoronary syndrome

作　　者：韦德宇[1] 丁晓梅[1,2] 苏浩[1,2] 胡昊[1,2] 陈东[1] 

机构地区：[1]安徽医科大学附属省立医院心内科 [2]安徽省心血管病研究所,安徽合肥230001

出　　处：《安徽医药》2011年第3期338-340,共3页Anhui Medical and Pharmaceutical Journal

摘　　要：目的观察IL-17、hs-CRP在急性冠脉综合征(ACS)患者血清中的水平变化,同时观察两者是否存在相关性,推测IL-17与斑块不稳定性的关系。方法选择113例患者分为四组:急性心肌梗死(AMI)40例,不稳定型心绞痛(UA)31例,稳定型心绞痛(SAP)18例,胸痛综合征(CPS)24例。患者入院后立即留取静脉血标本离心,存于-80℃的冰箱,采用ELISA法集中检测患者血清中的IL-17、hs-CRPc、TNI、CK-MB水平。结果 AMI组和UA组外周血清IL-17水平分别为(37.04±9.92)(、30.11±5.67)ng.L-1,明显高于SAP组的(20.95±5.08)ng.L-1和CPS组(15.81±7.65)ng.L-1(P<0.01)。AMI组和UA组患者hs-CRP水平分别为(39.21±14.42)(、11.57±3.71)mg.L-1,明显高于SAP组的(3.53±4.45)mg.L-1和CPS组(2.94±3.97)mg.L-1(P<0.05)。IL-17与hs-CRP Spearman相关系数r=0.364(P<0.001)。结论在ACS患者中血清中IL-17水平明显升高,与hs-CRP呈正相关,推测IL-17与动脉粥样硬化斑块不稳定性有关,参与了ACS的发病。Aim To observe the changes of IL-17 and hs-CRP in patients with acute coronary syndrome（ACS）,and whether there was correlation between the two or not,and to investigate the relationship between IL-17 and the instability of plaque.Methods 113 patients were divided into 4 groups：40 cases with acute myocardial infarction（AMI）,31 cases with unstable angina（UA）,18 patients with stable angina pectoris（SAP）,and 24 patients with chest pain syndrome（CPS）.All were taken blood from immediately after admission in,and centrifugal samples stored in-80℃ refrigerator to detect the serum levels of IL-17,hs-CRP,cTNI,CK-MB by ELISA.Results AMI and UA in peripheral blood levels of IL-17 [（37.04 ± 9.92）,（30.11 ± 5.67） ng·L-1] were significantly higher than the SAP（20.95 ± 5.08） ng·L-1 and the CPS（15.81 ± 7.65） ng·L-1（P0.01）.Levels of hs-CRP in AMI and UA[（39.21 ± 14.42）,（11.57 ± 3.71） mg·L-1],were significantly higher than the SAP（3.53 ± 4.45） mg·L-1 and the CPS gr（2.94 ±3.97）mg·L-1（P0.05）.IL-17 and hs-CRP were positively correlated（r=0.364,P0.001）.Conclusion The serum levels of IL-17 were significantly increased and was positively correlated with hs-CRP.We suggested that IL-17 becorrelated with the instability of atherosclerotic plaque,and also involved in the pathogenesis of ACS.

关 键 词：IL-17 HS-CRP 急性冠脉综合征 动脉粥样硬化 斑块 

分 类 号：R541.4[医药卫生—心血管疾病]