基底前脑巢蛋白免疫阳性神经元研究现状及展望  

The Current Situation and Prospects of the Studies on the Nestin-Immunoreactive Neurons in Basal Forebrain

作　　者：朱建华[1] 王勇[1] 

机构地区：[1]大理学院基础医学院人体解剖学教研室,大理671000

出　　处：《四川解剖学杂志》2010年第4期26-29,共4页Sichuan Journal of Anatomy

基　　金：大理学院高层次人才科研启动基金(No.201002)

摘　　要：目的阐述基底前脑nestin免疫阳性神经元的研究现状,为后续研究提供依据。方法对近年发表的有关基底前脑nestin免疫阳性神经元的文献进行分析和综述。结果在人和大鼠的基底前脑存在着一群能表达nestin的成熟神经元,这群神经元是区别于胆碱能神经元和γ-氨基丁酸能神经元的独立的神经元。其形态和分布与胆碱能神经元相似,向海马、大脑皮质及丘脑投射,与学习记忆及神经元的可塑性有关。结论基底前脑nestin免疫阳性神经元的化学属性、纤维联系及电生理特征等有待于进一步研究。这些研究将有助于我们了解成熟神经元表达nestin的功能意义,并为相关疾病的诊治提供新的视角。Objective To expound the current situation of the studies on the basal forebrain nestin-immunoreactive neurons（nestin-ir）,and provide evidences for the following study.Methods Reviewed the recently published literatures about the basal forebrain nestin-ir neurons.Results There are a group of mature nestin-ir neurons in the basal forebrain of rat and human,which are distinctive neurons different from basal forebrain cholinergic or GABAergic neurons.Nestin-ir neurons share similar morphology and distribution with those of cholinergic neurons,project to hippocampus,cerebral cortex and thalamus,and are relate to learning and memory and neural plasticity.Conclusion The neurochemical profile,connectivity and electrophysiology of nestin-ir neurons need further studies.These studies will facilitate us understanding the significance of nestin expressing in mature neurons,and provide new insight for diagnosis and treatment of related disease.

关 键 词：基底前脑 巢蛋白 胆碱能神经元 

分 类 号：R329[医药卫生—人体解剖和组织胚胎学]