重症患者右美托咪啶和咪达唑仑镇静效果的比较：Meta分析  

Efficacy of dexmedetomidine versus midazolam for sedation in critically ill patients： a Meta-analysis

作　　者：于涛[1] 董亮[1] 刘松桥[1] 杨毅[1] 邱海波[1] 

机构地区：[1]东南大学附属中大医院重症医学科,南京市210009

出　　处：《中华麻醉学杂志》2010年第11期1297-1300,共4页Chinese Journal of Anesthesiology

基　　金：基金项目：江苏省“科教兴卫工程”医学领军人才基金（2007）;江苏省“科教兴卫工程”医学重点人才基金（2007）

摘　　要：目的 采用Meta分析比较右美托咪啶和咪达唑仑用于重症患者镇静的效果.方法 检索PubMed、EMbase、Cochrane图书馆、万方数据库、CNKI、VIP等数据库,收集右美托咪啶和咪达唑仑用于重症患者镇静的临床随机对照研究.采用Cochrane协作网系统评价纳入文献的质量,采用Rev-Man 5.0软件对收集的患者资料进行Meta分析.结果 共纳入6项研究,包括613例患者,其中右美托咪啶组385例,咪达唑仑组228例.与咪达唑仑组比较,右美托咪啶组ICU住院时间缩短,机械通气时间、心动过缓、低血压和谵妄的发生率、病死率差异无统计学意义（P＞0.05）.结论 与咪达唑仑相比,右美托咪啶可缩短ICU住院时间,提示右美托咪啶有利于重症患者的转归.Objective To systematically review the efficacy of dexmedetomidine or midazolam for sedation in critically ill patients. Methods We searched the PubMed, EMBaes, Cochrane Library, Wanfang Database,CNKI and VIP for all randomized controlled trials （RCTs） about the efficacy of dexmedetomidine versus midazolam for sedation in severe cases. The quality of the studies was evaluated by the method recommended by Cochrane Collaboration. Meta-analysis was conducted using the Cochrane Collaboration＇s RevMan 5.0 software. Results Six RCTs involving 613 patients were included in our Meta-analysis. The results of Meta-analysis showed that the length of ICU stay was significantly shorter in group dexmedetomidine than in group midazolam. There were no significant differences in the duration of mechanical ventilation, incidences of bradycardia, hypotension and delirium and mortality rate between the two groups. Conclusion Dexmedetomidin can shorten the length of ICU stay and is beneficial for the outcome in critically ill patients.

关 键 词：右美托咪啶 咪达唑仑 清醒镇静 META分析 

分 类 号：R614[医药卫生—麻醉学]