麻痹性贝毒对肝脏和肾脏氧化损伤的影响  

Effects of PSP-induced oxidative stress in liver and kidney

作　　者：陈雪[1,2] 程金平[1] 张鉴达[1] 宋玉玲[1] 王文华[1] 于金莲[2] 

机构地区：[1]上海交通大学环境科学与工程学院,上海200240 [2]上海师范大学生命与环境科学学院,上海200234

出　　处：《海洋科学》2010年第12期93-95,共3页Marine Sciences

基　　金：上海科委科技攻关项目(08dz1206302)

摘　　要：为了探讨麻痹性贝毒(PSP)对肝脏和肾脏损伤的机制,采用膝沟藻毒素GTX-1,4对小鼠进行急性暴露,剂量为1μg/kg,时间分别为60、90、120min。结果发现,与对照组相比,肝脏染毒组中的还原型谷胱甘肽(GSH)含量没有显著变化;在肾脏中,60 min时染毒组GSH含量没有明显变化,90、120 min时GSH含量降低;两器官中抗氧化酶(GSH-Px、SOD)活性与对照组相比均无显著变化(P>0.05)。从而推断,GSH参与了PSP对肾脏损害的毒性过程;肾中GSH含量有可能作为PSP早期检测的敏感指标。Oxidative stress induced by paralytic shellfish poisoning（PSP） in liver and kidney was studied by comparing mice acutely exposed to GTX-1,4.The exposure dose was 1μg/kg with different durations of 60,90 and 120 min.The results found that the contents of GSH in liver changed slightly;in kidney,the contents of GSH were significantly decreased at 90 and 120min.The activities of GSH-Px and SOD were changed slightly in both organs（P 〉0.05）.These data indicate that GSH is involved in kidney injury of PSP;GSH content in kidney may be a sensitive indicator for detecting PSP.

关 键 词：麻痹性贝毒 氧化损伤 肝脏 肾脏 

分 类 号：Q179.1[生物学—水生生物学]