全肠外营养引起的肠道并发症及其预防  

Total parenteral nutrition induced intestinal complications and their prevention

作　　者：李运景[1] 李雪芹[1] 

机构地区：[1]中山大学附属中山医院药学部,广东中山528400

出　　处：《药物不良反应杂志》2010年第6期415-418,共4页Adverse Drug Reactions Journal

摘　　要：全肠外营养(TPN)长期应用可以引起肠道并发症。其临床表现为腹痛、腹泻、恶心、呕吐、水电解质紊乱,甚至休克。发生机制可能与长期使用TPN使肠黏膜萎缩、肠屏障功能受损,导致病菌过度繁殖、移位有关。TPN肠道并发症的预防措施如下:尽可能缩短TPN使用时间;尽早与肠内营养联合使用;长期TPN支持的患者,可在TPN中加入丙氨酰谷氨酰胺及生长激素等营养因子。Prolonged use of total parenteral nutrition（TPN） may induce intestinal complications.The clinical presentations of intestinal complications are abdominal pain,diarrhea,nausea,vomiting,water and electrolyte disturbance,and even a shock.The mechanisms of TPN-induced in testinal complications might be associated with atrophy intestinal mucosa and in testinal barrier damage,leading to bacterial overgrowth and translocation.The preventive measures for TPN-induced intestinal complications are as follows： th eduration of TPN use should be decreased if possible;TPN should be combined with enteral nutrition as early as possible.Alanyl-glutamine,growth hormone,and some other nutritional factors can be added to solutions for TPN in patients who were prolonged use of TPN.

关 键 词：全肠外营养 肠损害 细菌移位 并发症 

分 类 号：R459.3[医药卫生—治疗学]