孕期吸烟与先天性腹裂胎儿关系的Meta分析  

A Meta-analysis on the Association between Materal Smoking during Pregnancy and Prenatal Gastroschisis

作　　者：王来[1] 耿慧霞[2] 蒋建平[1] 

机构地区：[1]商丘医学高等专科学校,河南商丘476100 [2]商丘师范学院生命科学系,河南商丘476000

出　　处：《环境与职业医学》2010年第12期716-718,共3页Journal of Environmental and Occupational Medicine

基　　金：河南省教育厅自然科学计划项目(编号:2009C310013)

摘　　要：[目的]探讨孕期吸烟与先天性腹裂胎儿的关系,分析不同孕期和每天不同吸烟量对先天性腹裂的影响。[方法]分别检索6个中英文文献数据库,选择6篇符合纳入标准的文献,通过Review Manager 4.2和Stata软件进行Meta分析。[结果]孕期吸烟与先天性腹裂胎儿之间的合并效应值为OR=2.36(95%CI:2.02～2.76);每天吸烟量为10～20支及>20支的合并效应值分别为OR=2.29(95%CI:1.89～2.77)和OR=2.54(95%CI:1.68～3.85),吸烟量<10支的无统计学意义;孕期前三个月吸烟的合并效应值为OR=2.46(95%CI:1.52～3.98)。[结论]孕期吸烟尤其孕期前三个月吸烟与先天性腹裂胎儿具有显著相关性,此相关性随每天吸烟量的增加而增大。[Objective] To examine the association between maternal smoking during pregnancy and prenatal gastroschisis,also to investigate the effects of different pregnancy phases and the amount of smoking per day on gastroschisis.[Methods] Totally six studies published in Chinese and English literature databases were analyzed synthetically by Meta analysis through the Review Manager 4.2 and Stata software.[Results] The combined effect value of odds ratio（OR）between smoking during pregnancy and gastroschisis was 2.36[95% confidence interval（CI）：2.02-2.76].The combined effect value of OR was 2.29（95%CI：1.89-2.77）when the number of cigarettes smoked per day was between10 to 20,and 2.54（95%CI：1.68-3.85）when more than 20.There was no statistical significance of the OR value when cigarettes smoked less than 10 per day.The value of OR was 2.46（95%CI：1.52-3.98）when women were smoking during the first three months of their pregnancy.[Conclusion] Smoking in the first three months during pregnancy had significant correlation with prenatal gastroschisis,and this correlation increased with the increasing daily smoking amount.

关 键 词：吸烟 先天性腹裂 META分析 

分 类 号：R17[医药卫生—妇幼卫生保健]