苯乙烯对职业接触人群脂代谢的影响  

Influence of Styrene on the Lipid Metabolism in Occupational Exposed Persons

作　　者：郑能雄[1] 陈艳[1] 王李仁[1] 何颖荣[1] 沈波[1] 刘宝英[2] 陈锦[2] 

机构地区：[1]福州市疾病预防控制中心,福建福州350004 [2]福建医科大学公共卫生学院,福建福州350004

出　　处：《环境与职业医学》2010年第12期745-747,共3页Journal of Environmental and Occupational Medicine

基　　金：福建省卫生厅青年科研课题(编号:2007-2-45)

摘　　要：[目的]观察苯乙烯职业接触人员血脂代谢的指标,探讨苯乙烯对职业接触人员血脂代谢的影响。[方法]选择苯乙烯接触人员108名(男58名,女50名)和对照组人员115名(男60名,女55名),以总胆固醇(CHO)、三酰甘油(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)作为脂代谢的观察指标。比较苯乙烯职业接触人员和对照人员血脂指标,并对苯乙烯职业接触人员的观察指标和个体接触累计剂量、工龄等职业因素进行相关分析。[结果]苯乙烯接触组与对照组的CHO和LDL平均含量没有差异(P>0.05),接触组的TG平均含量高于对照组(P<0.05),HDL平均含量低于对照组(P<0.05)。接触组的HDL异常百分率高于对照组(P<0.05),其余指标异常百分率与对照组没有差异(P>0.05)。TG与工作场所苯乙烯平均浓度×工龄有关(P<0.05),与其他三因素无相关(P>0.05);HDL与个人接触剂量、工作场所苯乙烯平均浓度有相关(P<0.05)。[结论]苯乙烯可能引起职业接触者的TG含量升高和HDL含量降低。[Objective] To explore the effect of styrene on lipid metabolism in occupational exposed persons.[Methods] Indices of lipid metabolism total cholesterol（CHO）,triglyceride（TG）,high density lipoprotein（HDL）,and low density lipoprotein（LDL）were measured in 108 styrene exposed persons and 115 controls.The relevant factors such as personal exposure dose and length of service were monitored and recorded.Then the correlation of the exposue and effects was analysed.[Results] The contents of CHO and LDL showed no significance in the two groups（P 0.05）.TG was higher in the exposed persons than the controls,while HDL was lower（P 0.05）.The abnormal rate of HDL was higher in exposed group than the controls（P 0.05）,but other indices of lipid metabolism showed no significant difference between the two groups（P 0.05）.[Conclusion] Styrene may have some effects on lipid metabolism in exposed persons such as TG and HDL.

关 键 词：苯乙烯 脂代谢 三酰甘油 高密度脂蛋白 

分 类 号：R134.2[医药卫生—劳动卫生]