Human Spermicidal Activity of Passiflora edulis Extract  

作　　者：Angela M.Alvarez-Gómez1 Wálter Cardona-Maya1 Jorge Forero Angela P.Cadavid 

机构地区：[1]Grupo Reproducción,Universidad de Antioquia [2]Grupo de Inmunovirología,Universidad de Antioquia

出　　处：《Journal of Reproduction and Contraception》2010年第2期95-100,共6页生殖与避孕（英文版）

基　　金：WCM was supported by a fellowship from Colciencias, Colombia

摘　　要：Objective To evaluate the spermicidal activity of Passiflora edulis extract on human spermatozoa. Methods Human spermatozoa were incubated with P. edulis extracts and their motility and viability were evaluated; additionally, the cytotoxic effect of the extracts was evaluated by the tetrazolium bromide （MTT） reduction assay. Results The motility and viability were decreased immediately after treatment with a 21% dilution of the supernatant of the extract of P. edulis （P〈0.01）. No cytatoxic effect of the extracts studied was found on proliferation of MDBK and VERO cells. Conclusion These results may open the way for the use of P. edulis as a spermicidal product with less adverse effects.Objective To evaluate the spermicidal activity of Passiflora edulis extract on human spermatozoa. Methods Human spermatozoa were incubated with P. edulis extracts and their motility and viability were evaluated; additionally, the cytotoxic effect of the extracts was evaluated by the tetrazolium bromide （MTT） reduction assay. Results The motility and viability were decreased immediately after treatment with a 21% dilution of the supernatant of the extract of P. edulis （P〈0.01）. No cytatoxic effect of the extracts studied was found on proliferation of MDBK and VERO cells. Conclusion These results may open the way for the use of P. edulis as a spermicidal product with less adverse effects.

关 键 词：SPERMATOZOA SPERMICIDE CONTRACEPTION Pasiflora edulis 

分 类 号：R285[医药卫生—中药学]