反复自然流产夫妇染色体核型分析  

Karyotype analysis on couples with recurrent spontaneous abortion

作　　者：曹芳[1] 虞斌[1] 张晓青[1] 王晶[1] 吴晓妍[1] 黄瑞萍[1] 

机构地区：[1]南京医科大学附属常州妇幼保健院,江苏常州213000

出　　处：《现代生物医学进展》2010年第24期4707-4709,共3页Progress in Modern Biomedicine

摘　　要：目的:通过对反复自然流产夫妇的染色体核型进行分析,探讨反复自然流产与染色体核型异常的关系。方法:对1018对诊断为反复自然流产的夫妇,采集肘静脉血液,常规外周血细胞培养和染色体标本制备,行染色体核型分析。结果:1018对反复自然流产患者中,染色体异常者129例,占受检夫妇的12.67%。其中,平衡易位24例;罗伯逊易位12例;染色体多态80例;倒位11例;重复2例。结论:染色体核型异常是造成流产、死胎的重要因素之一,对反复自然流产患者进行细胞遗传学检查具有重要意义。Objective： To analyze the incidence of abnormal karyotypes and clinical value of chromosome analysis in spontaneous abortion.Methods： Chromosome analysis was performed on 1018 couples who were diagnosed spontaneous abortion in January 1996 ～ June 2010.Results： 129 abnormal karotypes were detected in 1018 cases（12.67%）,including 24 cases of balanced reciprocal translocation and 12 cases of Robertsonian translocations;80 cases of chromosome polymorphism;11 cases of inversions and 2 cases of duplication.Conclusion： Chromosome abnormality is one of the important factors of miscarriage and stillbirth.It is significant to analyze chromosomal in patients with early recurrent spontaneous abortion.

关 键 词：自然流产 染色体 核型 

分 类 号：R714.21[医药卫生—妇产科学]