急诊PCI前后不同冠状动脉病变支数纤维蛋白原水平分析  

The analysis of Fibrinogen Levels of Different Coronary Artery Disease in Emergency PCI

作　　者：单鸿伟[1] 陈凤英[1] 崔晓迎[1] 牛君义[1] 肖燕[1] 武隽忞 杜辉[1] 

机构地区：[1]内蒙古医学院附属医院急诊科,内蒙古呼和浩特010050

出　　处：《内蒙古医学杂志》2010年第10期1195-1197,共3页Inner Mongolia Medical Journal

摘　　要：目的:研究ST段抬高急性心肌梗死(ST-segment elevation myocardial infarction,STAMI)患者中单支、双支及多支病变行急诊经皮冠状动脉介入治疗前后的血浆纤维蛋白原(fibrinogen,FIB)水平的变化,从而分析急诊PCI术对不同冠状动脉病变支数患者血浆FIB水平的影响。方法:对142例STAMI患者于24 h内成功行冠状动脉造影及PCI术,根据冠状动脉造影结果分为单支病变组,双支病变组和多支病变组,在PCI术前及PCI术后12 h进行血浆FIB检测。结果:急诊PCI术前血浆FIB含量单支病变组2.31±0.82,低于双支病变组3.09±0.44和多支病变组3.12±0.71,有统计学意义(P<0.05),双支病变组和多支病变组间无统计学差异;PCI术后血浆FIB含量均增高,单支病变组3.74±0.54,双支病变组4.40±0.58和多支病变组5.17±1.49,多支病变组增高最为明显,且3组间均有统计学差异。结论:STAMI患者行急诊PCI术后不同冠状动脉病变支数患者血浆FIB含量均增高,多支病变患者FIB含量增高最为显著。Objective：To research the change of fibrinogen（FIB）levels of anterior-posterior emergency percutaneous coronary intervention（PCI） in the patient of ST-segment elevation myocardial infarction（STAMI） with single-vessel,double-vessel and multi-vessel coronary artery disease,thereby,to analyze the affection of plasma FIB levels of emergency PCI to different coronary artery disease.Methods： In 142 patients with STAMI,coronary arteriongraphy and PCI were performed in 24 h,they were divided into single-vessel group,double-vessel group and multi-vessel group,and plasma FIB were measured in front of PCI and 12 h after PCI.Results： The concentration of plasma FIB in front of PCI was lower single-vessel group（2.31±0.82） than double-vessel group（3.09±0.44） and multi-vessel group（3.12±0.71）（P〈0.05）,but it is not significant different between double-vessel group with multi-vessel group;the concentration of plasma FIB in behind of PCI was raised up in single-vessel group（3.74±0.54）,double-vessel group（4.40±0.58） and multi-vessel group（5.17±1.49）;and multi-vessel group was higher obviously,and there were significant different between groups.Conclusion：The concentration of plasma FIB of STAMI patient of different coronary artery disease was raised up in all groups after emergency PCI,and the patient of multi-vessel group was the most obviously.

关 键 词：急性心肌梗死 介入治疗 纤维蛋白原 

分 类 号：R541.4[医药卫生—心血管疾病]