不同应激状态下大鼠胃排空及脑肠肽含量的变化  

Changes of gastric emptying and brain-gut peptide in rats under different stress

作　　者：徐伟[1] 孙维峰[1] 梁静[1] 张娴娴[1] 刘玲[1] 李丽[1] 

机构地区：[1]广州军区广州总医院中医科,广州510010

出　　处：《中国中西医结合消化杂志》2010年第6期359-361,共3页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

基　　金：广东省中医药局立项资助(高强度运动及心理应激对大鼠消化机的影响及升降方的干预作用;No.2009286)

摘　　要：[目的]探讨不同应激状态对大鼠胃排空及胃动素(MOT)、胃泌素(GAS)的影响。[方法]Wistar大鼠32只,随机分成空白对照组、高强度运动应激组、心理应激组、高强度运动应激+心理应激组,每组8只。测定大鼠在高强度运动应激及心理应激后的胃排空及GAS、MOT的含量。[结果]与空白对照组比较,高强度运动应激组及心理应激大鼠的胃排空、GAS、MOT均明显下降(P<0.01或P<0.05);与高强度运动应激组比较,心理应激组及高强度运动+心理应激组胃排空率、GAS、MOT下降更明显(P<0.01或P<0.05);高强度运动+心理应激组与心理应激组比较差异无统计学意义(P>0.05)。[结论]高强度运动应激及心理应激均能引起胃排空率、GAS、MOT水平下降。高强度运动+心理应激对胃排空率、GAS、MOT的影响更大。[Objective] To study the effect of high-intensity exercise stress and psychological stress on gastric emptying and motilin（MOT）,gastrin（GAS）in rats.[Methods]Thirty-two Wistar rats were divided into 4 groups：control group,high-intensity exercise stress group,psychological stress group,high-intensity exercise plus psychological stress group.Gastric emptying ratios,GAS and MOT contents were measured after high-intensity of exercise and psychological stress.[Results]Compared with the control group.high-intensity exercise stress and psychological stress groups showed significantly decreased gastric emptying ratio and GAS and MOT contents（P〈0.01 or P〈0.05）;compared with the high-intensity exercise stress group,gastric emptying ratio and GAS and MOT contents in psychological stress group and high-intensity exercise plus psychological stress group decreased more significantly（P〈0.01 or P〈0.05）;there was no significant difference between high-intensity exercise plus psychological stress group and psychological stress group.[Conclusion]Both high-intensity exercise stress and psychological stress could decrease the gastric emptying rate,GAS and MOT contents,and the latter＇s effect was more significant.

关 键 词：应激 胃排空 胃泌素 胃动素 

分 类 号：R322.44[医药卫生—人体解剖和组织胚胎学]