髓过氧化物酶-463G/A基因多态性与原发性高血压相关性研究  

Association between myeloperoxidase-463G/A polymorphism and essential hypertension

作　　者：马慧元[1] 马丽雅[1] 方金瑞[1] 马华[1] 方砚[1] 苏鹏[1] 

机构地区：[1]甘肃省人民医院干三科,甘肃兰州730000

出　　处：《中国现代医学杂志》2010年第23期3580-3582,3587,共4页China Journal of Modern Medicine

摘　　要：目的探讨髓过氧化物酶(MPO)-463G/A基因的多态性与原发性高血压(EH)的易患关系。方法 EH患者107例,对照组97例,应用聚合酶链反应-限制性片段长度多态性(PCR-RELP)技术分析MPO-463G/A基因的多态性,并进行统计学分析。结果 EH患者GG、GA+AA基因型的分布频率分别是70.1%和29.9%,正常对照组分别是56.7%和43.3%,差异具有显著性(P<0.05);男性EH患者GG、GA+AA基因型的分布频率分别是78.1%和21.9%,男性对照组分别是57.4%和42.6%,差异具有显著性(P<0.05)。结论 MPO-463G/A基因的多态性与EH的易患性显著相关。该位点A基因的表达在EH的发生过程中起保护性作用,对男性的保护作用更明显。【Objective】 To study the relationship between the 463G/A polymorphism of myeloperoxidase（MPO） gene and essential hypertension（EH）.【Methods】 Polymerase chain reaction restriction fragment length polymorphism（PCR-RELP） technique was used to analyze the 463G/A polymorphism.The study covered 107 hypertensives and 97 controls.【Results】 The frequencies of MPO,GG,GA＋AA genotypes in hypertensives and controls were 70.1%,29.9% and 56.7%,43.3%.There was a significant difference in genotypes between hypertensives and controls（P〈 0.05）.The GG,GA ＋AA genotypes in male hypertensives and male controls were 78.1%,21.9% and 57.4%,42.6%,respectively.There was also a significant difference（P 〈0.05）.【Conclusions】 The 463G/A polymorphism of MPO gene influences the risk of EH.The A allele has protective function in EH occurrence which is more obvious in male hypertensives.

关 键 词：髓过氧化物酶 原发性高血压 基因多态性 

分 类 号：R544.1[医药卫生—心血管疾病]