黄芪多糖在大鼠阳离子化牛血清白蛋白肾炎中的影响  

Effects of Astragalus Polysaccharide on Nephritis Induced by Cationic Bovine Serum Albumin in Rats

作　　者：李世刚[1] 陈燕[1] 张永琦[1] 

机构地区：[1]三峡大学医学院,湖北宜昌443002

出　　处：《中药材》2010年第12期1913-1916,共4页Journal of Chinese Medicinal Materials

基　　金：三峡大学科研基金(0620070105)

摘　　要：目的:探讨黄芪多糖对大鼠阳离子化牛血清白蛋白(C-BSA)肾炎的药理作用。方法:采用C-BSA建立肾小球肾炎大鼠模型,用黄芪多糖腹腔注射治疗,取大鼠肾脏皮质、全血和尿液标本,分别做24 h尿蛋白定量、血清肌酐测定、肾脏病理形态学观察、红细胞天然免疫活性、红细胞膜CD35和CD44s数量。结果:与正常对照组比较,模型组大鼠24 h尿蛋白含量和细胞免疫复合物花环率(IC)显著增高(P<0.05),红细胞C3b受体花环率(C3b)和细胞膜表面CD35、CD44s分子数量显著降低(P<0.05),荧光检查证实有免疫复合物沉积;与模型组比较,黄芪多糖组24 h尿蛋白含量和IC表达较模型组显著下降(P<0.05),C3b和CD35、CD44s表达显著升高(P<0.05),荧光检查免疫复合物沉积明显减轻。结论:黄芪多糖能抑制肾脏的炎症免疫反应,改善红细胞免疫功能,具有良好治疗肾小球肾炎的作用。Objective：To study the effects of Astragalus polysaccharide on nephritis induced by cationic bovine serum albumin in rats.Methods：C-BSA induced nephritis model was utilized in rats.The effects of Astragalus polysaccharide on this model were investigated.Results：Proteinuria of the Astragalus polysaccharide group was alleviated.The pathological damages of the Astragalus polysaccharide group were less severe in comparison with the model group.The Astragalus polysaccharide group could improve erythrocyte immune function and increase the CD35 and CD44s contents of red blood cells.Conclusion：Astragalus polysaccharide exerts a good effect in alleviating glomerular immune inflammation and improving erythrocyte immune function in the treatment of C-BSA induced nephritis.

关 键 词：黄芪多糖 C-BSA肾炎 红细胞免疫 CD35 CD44S 

分 类 号：R285.5[医药卫生—中药学]