儿童青少年血脂升高危险因素的病例对照研究  

A case-control study on the risk factors of hyperlipemia in children and adolescents

作　　者：赵启慧[1] 沈冲[2] 朱伟光[1] 施小明[3] 沈谨[1] 刘巧[2] 袁超群[2] 王海茹[2] 倪川[4] 项丙淮[5] 陈宏 

机构地区：[1]宿迁市疾病预防控制中心,江苏宿迁223800 [2]南京医科大学公共卫生学院流行病与卫生统计学系 [3]中国疾病预防控制中心慢性病防治与社区卫生处 [4]宿迁市卫生局 [5]宿迁市沭阳县疾病预防控制中心 [6]宿迁市宿豫区疾病预防控制中心

出　　处：《中国预防医学杂志》2010年第12期1222-1225,共4页Chinese Preventive Medicine

基　　金：江苏省预防医学科研资助课题(Y200705)

摘　　要：目的探讨儿童青少年血脂升高的相关因素,为进一步开展高血脂疾病的早期预防提供理论依据。方法采用分层整群的方法抽取江苏省宿迁市宿豫区和沭阳县5~15岁年龄组儿童青少年为研究对象,以每个地区各年龄组内总胆固醇（TC）和甘油三酯（TG）高于第75百分位数（〉P75）为升高组,低于或等于第25百分位数（P25）为对照组进行病例对照研究。以问卷结合体格检查的形式,询问调查对象家长获得高血压家族史、饮食习惯、行为方式等因素并测定调查对象血压、身高、体质指数、TC和TG等指标。结果单因素分析结果显示,高血脂家族史、午饭地点与儿童青少年TG升高,有统计学关联（P〈0.05）;而超重、上学交通方式、午饭地点及牛奶摄入量与儿童青少年TC升高,有统计学关联（P〈0.05）。进一步进行分层分析结果表明,在宿豫区（城镇）对象中,午饭地点、上学交通方式、常吃零食与TC升高存在显著正相关,OR（95%CI）值分别为2.243（1.465~3.432）、2.496（1.672~3.727）和1.748（1.180~2.589）;常吃零食则与TG升高呈显著负相关,OR（95%CI）为0.492（0.286~0.847）。在沭阳县（乡村）对象中,牛奶摄入与TC升高呈显著正相关,OR（95%CI）为1.568（1.091~2.255）,而超重和午饭地点则分别与TC和TG呈负相关,OR（95%CI）分别为0.387（0.209~0.715）、0.689（0.481~0.988）。结论经济水平、家庭饮食、上学交通运动的能量消耗以及牛奶与零食的摄入是影响该地区儿童青少年血脂升高的重要因素。Objective To investigate the risk factors of hyperlipemia in children and adolescents and provide evidences for early prevention and control.Methods A case-control study was conducted and the subjects were recruited with a stratified cluster sampling method from children and adolescents aged 2~15 years in Suqian,Jiangsu province.The cases of hyperlipemia were defined as participants with either total cholesterol（TC） or triglyceride（TG） concentration above seventy-five percentage（P75）,and controls were defined as participants with TC and TG at lower twenty-five percentage（P25）.The investigation included physical examination and questionnaire.The questionnaire collected the family history of hypertension,dietary habit and lifestyle,etc.TC and TG were tested with standard laboratory procedures.Results A single factor analysis showed that TG concentrations were associated with the family history of hyperlipemia and lunch site,and TC concentrations were correlated with ways to go to school,lunch site and milk intake,respectively.Stratification analysis indicated that TC concentrations were positively correlated with lunch site（OR：2.243,95% CI：1.465-3.432）,ways to go to school（OR：2.496,95% CI：1.672-3.727）,milk intake（OR：1.568,95% CI：1.091-2.255） and taking snakes（OR：1.748,95% CI：1.180-2.589）,while TG concentrations were negatively correlated with taking snacks（OR：0.492,95% CI：0.286-0.847）,overweight（OR：0.387,95% CI：0.209-0.715）,and lunch site（OR：0.689,95% CI：0.481-0.988）,respectively.Conclusion The results suggested that

关 键 词：高血脂 儿童青少年 病例对照研究 

分 类 号：R179[医药卫生—妇幼卫生保健]