老年男性2型糖尿病患者甲状腺功能及甲状腺自身抗体水平研究  

Changes of Thyroid Function and Thyroid Autoantibody in Elderly Male Patients with Type 2 Diabetes

作　　者：陈陵霞[1] 苗懿德[1] 刘杰[1] 宝辉[1] 郏蓉[1] 褚琳[1] 魏雅楠[1] 

机构地区：[1]北京大学人民医院老年科,北京市100044

出　　处：《中国全科医学》2011年第8期843-844,848,共3页Chinese General Practice

摘　　要：目的探讨老年男性2型糖尿病患者甲状腺功能、甲状腺自身抗体的变化及相关影响因素。方法选取老年男性2型糖尿病患者97例(T2DM组)及非糖尿病患者155例(对照组)。采用化学发光法分别测定两组的甲状腺功能〔血清三碘甲状腺原氨酸(T3)、甲状腺素(T4)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺素(TSH)〕及甲状腺自身抗体〔抗甲状腺过氧化物酶抗体(aTPO)、抗甲状腺球蛋白抗体(aTG)〕水平。同时收集体质指数(BMI)、空腹血糖、糖化血红蛋白(HbA1c)、血脂等相关临床资料。对比分析两组患者上述指标间的差异及影响因素。结果 T2DM组患者T4水平较对照组显著降低〔(7.58±1.48)μg/dl与(8.01±1.63)μg/dl〕,aTG较对照组显著升高〔(77±130)U/ml与(44±60)U/ml〕,差异均有统计学意义(P<0.05)。相关分析结果显示:T4水平与FT4、FT3、T3水平及BMI呈正相关,与TSH呈负相关(P<0.01);aTG与aTPO呈正相关(P<0.01)。结论老年男性2型糖尿病患者甲状腺功能及甲状腺自身抗体已有改变,表现为T4水平下降,aTG水平升高。BMI对T4有影响,aTG与aTPO存在相关性。Objective To investigate the changes of thyroid function and thyroid autoantibody in male patients with type 2 diabetes and its influence factor.Methods 97 male patients with type 2 diabetes（T2DM group） and 155 non diabetes patients（control group） were included.Serum T3,T4,FT3,FT4,TSH,aTG and aTPO were tested by chemoluminescence method.Clinical data including BMI,fast glucose,HbA1c,Cholesterol,Triglyceride were collected simultaneously.Differences between the two groups and influence factors were analyzed statistically. Results T4 was significantly lower in T2DM group compared with control group（（7.58±1.48）μg/dl vs（8.01±1.63）μg/dl）（P0.05）;aTG was significantly higher in T2DM group compared with control group（（76.9±129.8）U/ml vs（44.2±60.2）U/ml）（P0.05）.Analysis showed that there was a positive correlation between T4 and FT4,FT3,T3 and BMI,and there was also a positive correlation between aTG and aTPO（P0.01）. Conclusion Thyroid function and thyroid autoantibody have changed in male patients with type 2 diabetes,with T4 decreasing and aTG increasing.BMI affected T4 in some degree,and there was association between aTG and aTPO.

关 键 词：糖尿病 2型 老年人 男人 甲状腺功能 甲状腺自身抗体 

分 类 号：R587.1[医药卫生—内分泌]