益气血补肝肾中药对再次体外受精—胚胎移植妊娠率的影响  

Effect of Herbal Medicines of Strengthening Qi and Blood and Tonifying Liver and Kidney on Pregnancy Rate in Patients Receiving Second In-vitro Fertilization and Embryo Transfer

作　　者：邓伟民[1] 赵彦鹏[1,2] 葛明晓[1] 张金玉[1] 郭新宇[1] 

机构地区：[1]广州军区广州总医院,广东广州510010 [2]广州中医药大学

出　　处：《广州中医药大学学报》2011年第2期124-127,共4页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：广东省中医药局科研课题(编号:2009437)

摘　　要：【目的】探讨辅助生育技术结合益气血补肝肾中药对再次体外受精—胚胎移植(IVF-ET)妊娠率的影响。【方法】将82例行周期标准长方案垂体降调节IVF-ET患者随机分成中药组(41例)及对照组(41例),中药组在第2次IVF开始前3个月经周期及IVF周期中均给予益气血补肝肾中药辨证治疗,对照组则不予中药,IVF周期开始后2组均采用标准长方案降调节超促排卵方案。对两组临床资料及结局进行分析。【结果】2组患者的获卵数、优质胚胎数比较差异无显著性意义(P>0.05)。中药组患者在应用人绒毛膜促性腺激素(HCG)日内膜厚度低于对照组(P<0.05);中药组患者的HCG日8～13 mm内膜所占百分比大于对照组(P<0.05);中药组胚胎种植率及妊娠率高于对照组(P<0.05)。【结论】在采取辅助生育技术的同时,运用中药益气血补肝肾法能提高子宫内膜容受性,从而提高胚胎种植率和妊娠率。Objective To observe the effect of herbal medicines of strengthening qi and blood and tonifying liver and kidney on pregnancy rate in patients receiving second in-vitro fertilization and embryo transfer（IVF-ET）.Methods Eighty-two infertility patients which failed in the first IVF-ET were equally randomized into herbal medicine group and control group.During the three menstrual cycles before IVF-ET treatment and in the period of IVF-ET treatment,herbal medicine group received Jingqian Granules,Jinghou Zengzhi Granules and Cu Huangti Granules,which had the actions of strengthening qi and blood and tonifying liver and kidney,according to the syndrome differentiation.And control group received gonadotrophin releasing hormone agonist（GnRH-a） for down-regulation and ovarian stimulation.The clinical data and outcomes were compared in the two groups.Results The difference of the number of retrieved oocytes and high-quality embryo was insignificant between the two groups（P〉0.05）.The thickness of endometria on the day of administration of human chorionic gonadotrophin（HCG） was thinner,the percentage of the endometria with 813 mm thick on HCG day was higher,and the embryo implantation rate and pregnancy rate were also higher in herbal medicine group than those in the control group（P〈0.05）.Conclusion The application of herbal medicines of strengthening qi and blood and tonifying liver and kidney can increase the embryo implantation rate and pregnancy rate in patients receiving assisted reproductive technology through increasing the endometrial receptivity.

关 键 词：经后增殖颗粒/治疗应用 促黄体颗粒/治疗应用 经前颗粒/治疗应用 益气血补肝肾法 体外受精一胚胎移植 妊娠率 

分 类 号：R271.9[医药卫生—中西医结合]