扩链法合成赖氨酸改性聚乳酸的研究  

Synthesis of Lysine Modified Polylactic Acid by Chain Extension

作　　者：舒荣德[1] 陈际达[1] 邱智萍[1] 高素照[1] 卜娟[1] 王天会[1] 

机构地区：[1]重庆大学化学化工学院,重庆400044

出　　处：《广州化工》2011年第6期56-59,共4页GuangZhou Chemical Industry

基　　金：重庆市自然科学基金项目(CSTC2008BB4056);重庆大学211工程三期创新人才培养计划建设项目(项目编号:S-09103)

摘　　要：以D,L-丙交酯为原料,辛酸亚锡为催化剂,赖氨酸为引发剂,丙交酯开环聚合制备双端羟基聚乳酸(HO-PLA-Lys-PLA-OH)寡聚体,经16,-六亚甲基二异氰酸酯(HDI)扩链获得赖氨酸改性的聚乳酸材料。用傅里叶红外光谱、核磁共振、接触角、粘度法等手段对赖氨酸改性聚乳酸结构和性能等进行了表征。结果表明:赖氨酸可以引发丙交酯聚合,产物为含赖氨酸的双端羟基聚乳酸寡聚体;扩链产物的粘均分子量是寡聚体的3.6倍,其接触角变大,亲水性降低。Oligomer of dihydroxyl-terminated PLA was synthesized via lactide ring-opening polymerization with lysine as initiator and stannous octoate as catalyst,then polymers of lysine modified PLA was synthesized through chain extension oligomer with 1,6-Diisocyanatohexane（HDI）.The product polymers were characterized with RTIR,1H-NMR,contact angle testing and viscosity method.The results indicated that lactide can be initiated by lysine,the oligomer was dihydroxyl-terminated PLA with one lysine in each molecule,and viscosity average molecular weight of chain extension product was 3.6 times larger than that of oligomer,the contact angle increased and the hydrophilicity decreased after chain extension taking place.

关 键 词：聚乳酸改性 赖氨酸改性聚乳酸 生物可降解材料 扩链 医用材料 

分 类 号：O633.14[理学—高分子化学]