青海贵德、同德大骨节病儿童内外环境中氟元素变化的调查  

The differences of fluorine contents between the internal and external environment of children with Kashin-Beck disease in Guide and Tongde of Qinghai

作　　者：蒋宁[1,2] 雷艳霞[1] 张强 谭武红[1] 张颖[4] 郑全美[4] 吴翠艳[1] 武世勋[1] 吴海坤 席淑华[4] 谭希旺[1] 孙贵范[4] 郭雄[1] 

机构地区：[1]西安交通大学医学院公共卫生系地方病研究所,陕西西安710061 [2]甘肃省武威市环境保护局,甘肃武威733000 [3]青海省地方病研究所,青海西宁811602 [4]中国医科大学公共卫生学院,沈阳110001

出　　处：《国外医学（医学地理分册）》2011年第1期36-39,共4页Foreign Medical Sciences：Section of Medgeography

基　　金：科技部十一五支撑计划资助项目(No.2007BAI25B004);国家自然科学基金资助项目(No.30972556;30630058);高等学校博士点科研专项基金资助项目(No.20090201110049);陕西省"13115"科技创新工程重大科技专项资助(No.2009ZDKG-79)

摘　　要：目的探讨大骨节病地区儿童与非大骨节病地区儿童内外环境中氟元素水平及其与大骨节病的关系。方法采用氟离子选择电极法测定大骨节病地区与非大骨节地区水、土和粮食中以及大骨节病地区患儿与内、外对照组儿童的尿、发中的氟元素含量。结果①大骨节病地区水中氟含量为(0.24±0.10)mg/L、土中氟含量为(472.94±83.40)mg/kg和小麦中氟含量为(2.04±0.35)mg/kg显著低于非大骨节病地区水中氟含量为(0.26±0.08)mg/L、土中氟含量为(526.60±70.25)mg/kg、小麦中氟含量为(2.33±0.411)mg/kg;②大骨节病组儿童尿氟含量(0.87±0.34)mg/L、发氟含量(7.24±1.36)mg/kg及内对照组尿氟含量(0.92±0.42)mg/L;发氟含量(8.12±1.46)mg/kg显著高于外对照组尿氟含量(0.67±0.27)mg/L;发氟含量(7.24±1.36)mg/kg。结论青海大骨节病儿童外环境氟元素含量偏低,而体内环境偏高,呈现体内、外环境氟元素含量不一致现象。Objective To investigate the differences of fluorine concentration between the internal and external environment of children with Kashin-Beck disease （KBD） in KBD and non-KBD areas to understand the relationship between fluorine and KBD. Methods Samples of drinking water, food, soil, hair and urine collected from children both KBD, the healthy and their family＇s in the KBD and non-KBD areas of Guide and Tongde in Qinhai, and determinated the fluorine concentration using fluoride ion selective electrode. Results （1） Fluorine contents in drinking water： （0.24±0.10） rag/L, soil： （472.94 ± 83.40） mg/kg and wheat： （2.04±0.35） mg/kg in KBD area was lower than that in non-KBD area water ： （0.26 ±0.08） mg/L, soil： （526.60 ± 70.25） mg/kg, wheat ： （2.33±0. 411） mg/kg （2） Fluorine contents of urine： （0.87±0.34） mg/L and hair, （8.12±1.46） mg/kg of KBD children group and the healthy control urine： （0.92±0.42） mg/Land hair： （8.12±1.46） that of non-KBD area urine （0. 67±0.27） mg/L and hair： （7.24±1.36） mg/kg. Conclusion mg/kg were higher than Fluorine contents of the external environment were significantlylower, but higher in the internal environment of KBD children in Qinghai. It indicated that fluorine contents between the internal and the external environment of human body were inconsistencies.

关 键 词：大骨节病 儿童 氟 调查 

分 类 号：R684.1[医药卫生—骨科学]