绞股蓝总皂苷对体内外血栓及凝血功能的影响  

INFLUENCE OF GYPENOSIDES ON THROMBUS AND COAGULATION FUNCTION IN VIVO AND IN VITRO

作　　者：张小丽[1] 刘珍[1] 朱自平[1] 杨甫昭[1] 谢人明[1] 

机构地区：[1]陕西省中医药研究院药理室,西安710003

出　　处：《华西药学杂志》1999年第5期335-337,共3页West China Journal of Pharmaceutical Sciences

基　　金：陕西省科委资助

摘　　要：以静脉注射高分子右旋糖苷（ｈｉｇｈｅｒ ｍ ｏｌｅｃｕｌａｒ ｗ ｅｉｇｈｔｄｅｘｔｒａｎ，ＨＭＷ Ｄ）造模，使实验动物的体内外血栓形成时间延长，凝血功能发生障碍。绞股蓝总皂苷（ｇｙｐｅｎｏｓｉｄｅｓ，ＧＰｓ）对以ＨＭＷ Ｄ 所致的血栓形成时间缩短具有较强的对抗作用，对ＨＭＷ Ｄ引起的凝血时间及凝血酶原时间（ＰＴ）的缩短亦具有较强对抗作用，对白陶土部分凝血活酶时间（ＫＰＴＴ）缩短有一定的延长作用，但无统计学意义。A model was established by intravenous injection of higher molecular weight dextran (HMWD), which exhibited extended thrombus development process and malfunctioned coagulation in vivo and in vitro. The results showed that, with the model animals, gypenosides (GPs) significantly reduced the length, fresh and dry weight of thrombus in vitro and shortened thrombosis time, lengthened coagulation time in vivo and prothrombin time in vitro, and significantly increased kaolin part thromboplastin time (KPTT).

关 键 词：绞股蓝总皂苷 高分子右旋糖苷 血栓 凝血功能 

分 类 号：R285.5[医药卫生—中药学]